CIRM Regenerative Medicine Research Training Program
Grant Award Details
Grant Type:
Grant Number:
EDUC4-12766
Investigator(s):
Award Value:
$5,373,742
Status:
Active
Progress Reports
Reporting Period:
Year 1
Reporting Period:
Year 2
Grant Application Details
Application Title:
CIRM Regenerative Medicine Research Training Program
Statement of Benefit to California:
A major goal of regenerative medicine is to repair damaged tissue. Our CIRM scholars have research programs that focus on developing new methods to differentiate human induced pluripotent stem cells (iPSCs) into specific cell types for regeneration of diseased tissues. Our program will benefit the California economy by training highly skilled scientists who will take leading positions in California’s research institutions and the biotechnology industry. These scientists will also create technology that will be the basis of creating jobs in the biomedical industry. For instance, new stem cell lines could be valuable for biotechnology companies and researchers who are screening for drug compounds for regenerative medicine. Furthermore, our CIRM scholars are working closely with California companies to develop new equipment and analysis software that could be the basis for new product lines or new businesses. As new regenerative therapies come to fruition, we anticipate that California medical centers will be leading the way.
Ultimately, the most important contribution of our CIRM scholars may be to improve the health of Californians. Diseases that are the target of regenerative medicine are major causes of mortality and morbidity, resulting in billions of dollars in healthcare costs and lost days at work. As we continue our efforts in medical research, we hope to one day unlock the secrets of tissue development and repair. This knowledge will help medical researchers develop beneficial therapies beyond what is currently available and potentially improve the quality of life and life expectancy of patients who suffer from disease.
Publications
- Hum Mutat (2022): Biallelic pathogenic variants in COX11 are associated with an infantile-onset mitochondrial encephalopathy. (PubMed: 36030551)
- bioRxiv (2023): Comparative analysis between single-cell RNA-seq and single-molecule RNA FISH indicates that the pyrimidine nucleobase idoxuridine (IdU) globally amplifies transcriptional noise. (PubMed: 36993609)
- Cell (2022): Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain. (PubMed: 36179668)
- Cell Rep (2023): Neurons require glucose uptake and glycolysis in vivo. (PubMed: 37027294)
- Epilepsia (2023): Patient-derived SLC6A1 variant S295L results in an epileptic phenotype similar to haploinsufficient mice. (PubMed: 37501613)
- PLoS Biol (2022): Primary and metastatic tumors exhibit systems-level differences in dependence on mitochondrial respiratory function. (PubMed: 36137002)
- Cell Stem Cell (2022): A reference human induced pluripotent stem cell line for large-scale collaborative studies. (PubMed: 36459969)
- bioRxiv (2023): Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production. (PubMed: 37904938)
- Neurobiol Dis (2023): Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets. (PubMed: 36990364)