Publications by CIRM grantees

The following list of publications describe research carried out with CIRM funding. Click on the publication title for a brief summary of the research and for more information about the CIRM grants that contributed to the research.

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Year Journal
Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons. 2017 Biomaterials
Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis. 2017 Sci Rep
Wnt/beta-catenin activation and macrophage induction during liver cancer development following steatosis. 2017 Oncogene
Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions. 2017 Front Mol Neurosci
Transplantation of wild-type mouse hematopoietic stem and progenitor cells ameliorates deficits in a mouse model of Friedreich's ataxia. 2017 Sci Transl Med
A novel protein-engineered hepatocyte growth factor analog released via a shear-thinning injectable hydrogel enhances post-infarction ventricular function. 2017 Biotechnol Bioeng
Maintenance of neural progenitor cell stemness in 3D hydrogels requires matrix remodelling. 2017 Nat Mater
Use of the DICE (Dual Integrase Cassette Exchange) System. 2017 Methods Mol Biol
DNA-Mediated Gene Therapy in a Mouse Model of Limb Girdle Muscular Dystrophy 2B. 2017 Mol Ther Methods Clin Dev
Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear. 2017 Sci Rep
A minimally sufficient model for rib proximal-distal patterning based on genetic analysis and agent-based simulations. 2017 Elife
Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma. 2017 Cell
Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma. 2017 Nature
Wrapped to Adapt: Experience-Dependent Myelination. 2017 Neuron
Placental mesenchymal stromal cells seeded on clinical grade extracellular matrix improve ambulation in ovine myelomeningocele. 2017 J Pediatr Surg
Fetal surgical repair with placenta-derived mesenchymal stromal cell engineered patch in a rodent model of myelomeningocele. 2017 J Pediatr Surg
Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice. 2017 Stem Cell Reports
Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network. 2017 Proc Natl Acad Sci U S A
The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1. 2017 Cell Death Differ
Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability. 2017 Neuropsychopharmacology
Reliable Identification of Living Dopaminergic Neurons in Midbrain Cultures Using RNA Sequencing and TH-promoter-driven eGFP Expression. 2017 J Vis Exp
Smek promotes corticogenesis through regulating Mbd3's stability and Mbd3/NuRD complex recruitment to genes associated with neurogenesis. 2017 PLoS Biol
A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer. 2017 Nat Commun
Tissue Engineering Functional Gastrointestinal Regions: The Importance of Stem and Progenitor Cells. 2017 Cold Spring Harb Perspect Med
Created of Warm Blood and Nerves: Restoring an Enteric Nervous System in Organoids. 2017 Cell Stem Cell
A Novel Hybrid Compound LLP2A-Ale Both Prevented and Rescued the Osteoporotic Phenotype in a Mouse Model of Glucocorticoid-Induced Osteoporosis. 2017 Calcif Tissue Int
Neural Crest Cell Implantation Restores Enteric Nervous System Function and Alters the Gastrointestinal Transcriptome in Human Tissue-Engineered Small Intestine. 2017 Stem Cell Reports
Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells. 2017 Stem Cells Transl Med
Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice. 2017 Nat Protoc
Detection of Pentosidine Cross-Links in Cell-Secreted Decellularized Matrices Using Time Resolved Fluorescence Spectroscopy. 2017 ACS Biomater Sci Eng
Creation of a Novel Humanized Dystrophic Mouse Model of Duchenne Muscular Dystrophy and Application of a CRISPR/Cas9 Gene Editing Therapy. 2017 J Neuromuscul Dis
A novel Alzheimer's disease drug candidate targeting inflammation and fatty acid metabolism. 2017 Alzheimers Res Ther
The L1 adhesion molecule normalizes neuritogenesis in Rett syndrome-derived neural precursor cells. 2017 Biochem Biophys Res Commun
Modeling neuro-immune interactions during Zika virus infection. 2017 Hum Mol Genet
Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models. 2017 Stem Cells Int
hESC-derived photoreceptors survive and integrate better in immunodeficient retina. 2017 Stem Cell Investig
Systemic Neutrophil Depletion Modulates the Migration and Fate of Transplanted Human Neural Stem Cells to Rescue Functional Repair. 2017 J Neurosci
Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification. 2017 Cell Stem Cell
Prognostic Significance of Left Ventricular Fibrosis in Patients With Congenital Bicuspid Aortic Valve. 2017 Am J Cardiol
Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusion. 2017 JCI Insight
Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation. 2017 Cell Stem Cell
TRPC Channels and Mental Disorders. 2017 Adv Exp Med Biol
Differentiation of V2a interneurons from human pluripotent stem cells. 2017 Proc Natl Acad Sci U S A
iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. 2017 Neuron
Contractile force generation by 3D hiPSC-derived cardiac tissues is enhanced by rapid establishment of cellular interconnection in matrix with muscle-mimicking stiffness. 2017 Biomaterials
Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion. 2017 Aging Cell
Genome Editing Techniques and Their Therapeutic Applications. 2017 Clin Pharmacol Ther
Characterization of the Corneal Subbasal Nerve Plexus in Limbal Stem Cell Deficiency. 2017 Cornea
A 3D Tissue-Printing Approach for Validation of Diffusion Tensor Imaging in Skeletal Muscle. 2017 Tissue Eng Part A
Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal. 2017 Biol Open

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