Publications by Grantees

The following list of publications describe research carried out with CIRM funding. Click on the publication title for a brief summary of the research and for more information about the CIRM grants that contributed to the research.

Title Year Journal
Human iPSC Generation from Antigen-Specific T Cells. 2019 Methods Mol Biol
Human iPSCs can be differentiated into notochordal cells that reduce intervertebral disc degeneration in a porcine model. 2019 Theranostics
Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. 2019 Nat Biotechnol
Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering. 2019 Stem Cells Int
Identification of preexisting adaptive immunity to Cas9 proteins in humans. 2019 Nat Med
Improved Computational Identification of Drug Response Using Optical Measurements of Human Stem Cell Derived Cardiomyocytes in Microphysiological Systems. 2019 Front Pharmacol
In Utero Treatment of Myelomeningocele with Placental Mesenchymal Stromal Cells – Selection of an Optimal Cell Line in Preparation for Clinical Trials. 2019 J Pediatr Surg
Inhibition of invasive pancreatic cancer: restoring cell apoptosis by activating mitochondrial p53. 2019 Am J Cancer Res
Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis. 2019 Kidney Int
Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1. 2019 N Engl J Med
LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. 2019 Sci Rep
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. 2019 Nature
LRRK2 modifies alpha-syn pathology and spread in mouse models and human neurons. 2019 Acta Neuropathol
Macrophage polarization impacts tunneling nanotube formation and intercellular organelle trafficking. 2019 Sci Rep
Mesenchymal Stem Cells Reduce Corneal Fibrosis and Inflammation via Extracellular Vesicle-Mediated Delivery of miRNA. 2019 Stem Cells Transl Med
Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle. 2019 Cell Rep
Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease. 2019 Cell Rep
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment. 2019 Cell
Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. 2019 Cell Stem Cell
Modeling Snyder-Robinson Syndrome in multipotent stromal cells reveals impaired mitochondrial function as a potential cause for deficient osteogenesis. 2019 Sci Rep
Modeling Spatial Correlation of Transcripts with Application to Developing Pancreas. 2019 Sci Rep
Multiscale, multispectral fluorescence lifetime imaging using a double-clad fiber. 2019 Opt Lett
Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes. 2019 FASEB J
Notch Inhibition Prevents Differentiation of Human Limbal Stem/Progenitor Cells in vitro. 2019 Sci Rep
Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells. 2019 Semin Immunopathol
Online measurement of oxygen enables continuous noninvasive evaluation of human-induced pluripotent stem cell (hiPSC) culture in a perfused 3D hollow-fiber bioreactor. 2019 J Tissue Eng Regen Med
Paramagnetic Fluorinated Nanoemulsions for in vivo F-19 MRI. 2019 Mol Imaging Biol
Phenotypic Variation Between Stromal Cells Differentially Impacts Engineered Cardiac Tissue Function. 2019 Tissue Eng Part A
Potential long-term treatment of hemophilia A by neonatal co-transplantation of cord blood-derived endothelial colony-forming cells and placental mesenchymal stromal cells. 2019 Stem Cell Res Ther
Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction. 2019 Cell Res
Preliminary Results of a Phase 1/2 Clinical Study of Zinc Finger Nuclease-Mediated Editing of BCL11A in Autologous Hematopoietic Stem Cells for Transfusion-Dependent Beta Thalassemia 2019 Blood
Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation. 2019 Biochem Biophys Res Commun
Promoting remyelination through cell transplantation therapies in a model of viral-induced neurodegenerative disease. 2019 Dev Dyn
Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function. 2019 PLoS One
PTPsigma inhibitors promote hematopoietic stem cell regeneration. 2019 Nat Commun
Receptor subtype discrimination using extensive shape complementary designed interfaces. 2019 Nat Struct Mol Biol
Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. 2019 Nat Commun
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors. 2019 Nat Commun
Single-cell genomics identifies cell type-specific molecular changes in autism. 2019 Science
Skeletal Stem Cell-Schwann Cell Circuitry in Mandibular Repair. 2019 Cell Rep
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. 2019 Elife
Spinal Angulation: A Limitation of the Fetal Lamb Model of Myelomeningocele. 2019 Fetal Diagn Ther
Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS. 2019 Nat Med
Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells. 2019 Gene Ther
Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease. 2019 Elife
T cell antigen discovery via signaling and antigen-presenting bifunctional receptors. 2019 Nat Methods
TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment. 2019 Cell Stem Cell
The application of human amniotic membrane in the surgical management of limbal stem cell deficiency. 2019 Ocul Surf
The lymphoid-associated interleukin 7 receptor (IL7R) regulates tissue-resident macrophage development. 2019 Development
The role of cellular interactions in the induction of hepatocyte polarity and functional maturation in stem cell-derived hepatic cells. 2019 Differentiation