| A Method to Enrich Functional Human Paneth Cells in Induced Pluripotent Stem Cell-Derived Intestinal Organoids. |
2026 |
Cell Mol Gastroenterol Hepatol |
| A modular platform for automated organoid culture and longitudinal imaging. |
2026 |
Sci Rep |
| A region-delineated snRNA-seq atlas of mouse spinal cord across lifespan resolves the interaction of normative aging programs with SOD1-G93A ALS. |
2026 |
bioRxiv |
| A review exploring the translational perspective of artificial intelligence in drug discovery and formulation development. |
2026 |
Ann Pharm Fr |
| A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex. |
2026 |
Science |
| Aberrant Protein S-Nitrosylation Mimics the Effect of Rare Genetic Mutations in Neurodegenerative Diseases. |
2026 |
J Neurochem |
| Antimicrobial proteins regulating neuroinflammation. |
2026 |
Ann Med |
| Biological pacemaker induced by focal cardiac transduction with AAV-TBX18. |
2026 |
Mol Ther |
| Brinzolamide microsponge-loaded in situ gel for sustained ocular delivery: design, characterization and in vivo evaluation. |
2026 |
Naunyn Schmiedebergs Arch Pharmacol |
| Clinical Outcomes of Lentiviral Vector Gene Therapy for Sickle Cell Disease. |
2026 |
Blood Adv |
| Comprehensive Ocular Characteristics in Cystinosis after Hematopoietic Stem-Cell Gene Therapy Over 24 Months. |
2026 |
Am J Ophthalmol |
| Concordant transcriptional and morphological remodeling revealed by in vivo Perturb-CLEAR. |
2026 |
bioRxiv |
| Cystinosin regulates Na(+)/H(+) exchanger 3 trafficking and function in kidney proximal tubular cells. |
2026 |
EMBO Rep |
| Development and validation of a potency assay matrix for optimized and consistent manufacture of clinical mesenchymal stem/stromal cells. |
2026 |
Front Immunol |
| Dissecting gene regulatory networks governing human cortical cell fate. |
2026 |
Nature |
| Dynamic Reorganization of Developmental to Adult Genome Topology Controls the Initiation and Stabilization of the Human Muscle Stem Cell State. |
2026 |
bioRxiv |
| Epigenetic and Transcriptional Programs Define Osteosarcoma Subtypes and Establish Targetable Vulnerabilities. |
2026 |
Cancer Discov |
| Feasibility and safety of cellular therapy for in-utero repair of myelomeningocele (CuRe Trial): a first-in-human, phase 1, single-arm study. |
2026 |
Lancet |
| Functional validation of the novel KIF5A p.R17Q VUS reveals defective axonal transport in iPSC-motoneurons from a SPG10 patient. |
2026 |
Front Genet |
| Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq. |
2026 |
bioRxiv |
| Hematopoietic Stem-Cell Gene Therapy for Cystinosis. |
2026 |
N Engl J Med |
| Human cardiac organoids for disease modeling and drug discovery. |
2026 |
Trends Mol Med |
| In vivo multiomic Perturb-seq with enhanced nuclear gRNA capture. |
2026 |
bioRxiv |
| Lesion-remote astrocytes govern microglia-mediated white matter repair. |
2026 |
Nature |
| Neural stem cell delivery of oncolytic CRAd-S-pk7 immunotherapy for stage 3 ovarian cancer: Dose-regimen studies. |
2026 |
Mol Ther Oncol |
| On the interpretation of astrocytic calcium signalling with graphene oxide electrodes. |
2026 |
Nat Nanotechnol |
| Oxidative stress-regulatory role of miR-10b-5p in the diabetic human cornea revealed through integrated multi-omics analysis. |
2026 |
Diabetologia |
| Probing neuropsychiatric disorders through in vivo CRISPR screening. |
2026 |
Curr Opin Genet Dev |
| Protocol for inducing dorsal spinal sensory interneurons from mouse embryonic stem cell-derived neuromesodermal progenitors. |
2026 |
STAR Protoc |
| RABEP1 regulates neutrophil migration via endosomal recycling and actin polymerization. |
2026 |
J Leukoc Biol |
| Reconstructing human corticogenesis: Insights from cerebral organoids into neurodevelopment and disease modeling. |
2026 |
Dev Cell |
| Redirection of sphingolipid metabolism drives cytoskeletal defects in SPLIS and reveals ROCK inhibition as therapy. |
2026 |
J Clin Invest |
| Single-Cell Analysis Reveals Peripheral Helper T Cells in Rheumatoid Arthritis-Related Interstitial Lung Disease. |
2026 |
Arthritis Rheumatol |
| Single-Cell Proteomics Reveals Novel Cell Phenotypes in Marfan Mouse Aneurysm. |
2026 |
Mol Cell Proteomics |
| Syndecan-1 Promotes Alveolar Type 2 Epithelial Cell Senescence during Lung Fibrosis. |
2026 |
bioRxiv |
| [(18)F]FDG-PET and [(18)F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation. |
2025 |
Sci Rep |
| A human-specific regulatory mechanism revealed in a pre-implantation model. |
2025 |
Nature |
| A Living Organoid Biobank of Crohn’s Disease Patients Reveals Distinct Clinical Correlates of Molecular Disease Subtypes. |
2025 |
medRxiv |
| A micro-metabolic rewiring assay for assessing hypoxia-associated cancer metabolic heterogeneity. |
2025 |
Bioact Mater |
| A Rare Hematopoietic Stem Cell-Derived Megakaryocyte Progenitor Accumulates via Enhanced Survival and Contributes to Exacerbated Thrombopoiesis Upon Aging. |
2025 |
Aging Cell |
| A simple approach of nuclei isolation for single nucleus multiome sequencing. |
2025 |
J Mol Cell Cardiol |
| A single-cell and spatial genomics atlas of human skin fibroblasts reveals shared disease-related fibroblast subtypes across tissues. |
2025 |
Nat Immunol |
| A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity. |
2025 |
Haematologica |
| Aberrant cytoplasmic localization of MLH1 characterizes a cell population that seeds breast cancer recurrence. |
2025 |
Nat Commun |
| Aberrant S-nitrosylation in the TCA cycle contributes to mitochondrial dysfunction, energy compromise, and synapse loss in neurodegenerative diseases. |
2025 |
Neurotherapeutics |
| Accelerated 3D qCEST of the Spine in a Porcine Model Using MR Multitasking at 3T. |
2025 |
NMR Biomed |
| Accelerated Tempo of Cortical Neurogenesis in Down Syndrome. |
2025 |
bioRxiv |
| Acholinebio-ionicliquid-functionalized gelatin methacryloyl hydrogel for chronic wound healing |
2025 |
European Polymer Journal |
| Active telomere elongation by a subclass of cancer-associated POT1 mutations. |
2025 |
Genes Dev |
| Adipose tissue ageing: implications for metabolic health and lifespan. |
2025 |
Nat Rev Endocrinol |
