Publications by Grantees

The following list of publications describe research carried out with CIRM funding. Click on the publication title for a brief summary of the research and for more information about the CIRM grants that contributed to the research.

Title Year Journal
Present and Future Modeling of Human Psychiatric Connectopathies With Brain Organoids. 2023 Biol Psychiatry
Presentation of Human Neural Stem Cell Antigens Drives Regulatory T Cell Induction. 2023 J Immunol
Profiling of repetitive RNA sequences in the blood plasma of patients with cancer. 2023 Nat Biomed Eng
Purification and functional characterization of novel human skeletal stem cell lineages. 2023 Nat Protoc
Pushing the boundaries of brain organoids to study Alzheimer’s disease. 2023 Trends Mol Med
Reversing lysosome-ribosome circuit dysregulation mitigates C9FTD/ALS neurodegeneration and behaviors. 2023 Hum Mol Genet
RNA editing: Expanding the potential of RNA therapeutics. 2023 Mol Ther
RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice. 2023 Blood
Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis. 2023 Nat Commun
Single mRNA detection of Wnt signaling pathway in the human limbus. 2023 Exp Eye Res
Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance. 2023 Sci Adv
Sonogenetic control of multiplexed genome regulation and base editing. 2023 Nat Commun
Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus. 2023 Nat Biomed Eng
Stem Cell-Based Organoid Models of Neurodevelopmental Disorders. 2023 Biol Psychiatry
Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates. 2023 Elife
Sustained postconfluent culture of human mammary epithelial cells enriches for luminal and c-Kit+ subtypes. 2023 Breast Cancer Res
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production. 2023 bioRxiv
T-allo10 Infusion after αβ depleted-HSCT in Children and Young Adults with Hematologic Malignancies: Improved Immune Reconstitution in the Absence of Severe GvHD 2023 Transplantation and Cellular Therapy
Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets. 2023 Neurobiol Dis
Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD(4)-selective WNT surrogate in mice. 2023 Nat Commun
Transcriptomic Effects on the Mouse Heart Following 30 Days on the International Space Station. 2023 Biomolecules
TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs. 2023 Proc Natl Acad Sci U S A
Tumor inflammation-associated neurotoxicity. 2023 Nat Med
Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes. 2023 Dev Cell
Understanding Fibroblast Heterogeneity in Form and Function. 2023 Biomedicines
Wnt activation as a potential therapeutic approach to treat partial limbal stem cell deficiency. 2023 Sci Rep
A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs. 2022 Nat Commun
A randomized placebo-controlled phase 3 study of mesenchymal stem cells induced to secrete high levels of neurotrophic factors in amyotrophic lateral sclerosis. 2022 Muscle Nerve
A reference human induced pluripotent stem cell line for large-scale collaborative studies. 2022 Cell Stem Cell
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery. 2022 Cell Stem Cell
Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice. 2022 Cell Rep
Adapting Physiology in Functional Human Islet Organogenesis. 2022 Front Cell Dev Biol
Adult Expression of Tbr2 Is Required for the Maintenance but Not Survival of Intrinsically Photosensitive Retinal Ganglion Cells. 2022 Front Cell Neurosci
Advancing preclinical models of psychiatric disorders with human brain organoid cultures. 2022 Mol Psychiatry
Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy. 2022 Nat Neurosci
An Ex Vivo 3D Tumor Microenvironment-Mimicry Culture to Study TAM Modulation of Cancer Immunotherapy. 2022 Cells
Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication. 2022 Nat Med
Antibody screening data of human midgestation liver cells with a focus on hematopoietic, liver sinusoidal endothelial, and hepatoblast cell-populations. 2022 BMC Res Notes
Biallelic pathogenic variants in COX11 are associated with an infantile-onset mitochondrial encephalopathy. 2022 Hum Mutat
Biomarkers of in vivo limbal stem cell function. 2022 Ocul Surf
Brain organoids, consciousness, ethics and moral status. 2022 Semin Cell Dev Biol
c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity. 2022 iScience
Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation. 2022 Cell
CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma. 2022 Nat Commun
Cell Morphology as an In Vivo Parameter for the Diagnosis of Limbal Stem Cell Deficiency. 2022 Cornea
Cloud-controlled microscopy enables remote project-based biology education in underserved Latinx communities. 2022 Heliyon
Collateral Arteriogenesis Involves a Sympathetic Denervation That Is Associated With Abnormal alpha-Adrenergic Signaling and a Transient Loss of Vascular Tone. 2022 Front Cardiovasc Med
Comment on: Long-Term Outcome After Superficial Keratectomy of the Abnormal Epithelium for Partial Limbal Stem Cell Deficiency. 2022 Am J Ophthalmol
COVID-19 vaccination elicits an evolving, cross-reactive antibody response to epitopes conserved with endemic coronavirus spike proteins. 2022 Cell Rep
Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs. 2022 Front Endocrinol (Lausanne)