Publications by Grantees

CIRM funding supported the following publications. Click on the publication title for a brief summary of the research and for more information:

Title Year Journal
Implantation of engineered adipocytes suppresses tumor progression in cancer models. 2025 Nat Biotechnol
Integrated Longitudinal Transcriptomic and Proteomic Analysis of the Murine Lung Response to Influenza A Virus. 2025 Am J Respir Cell Mol Biol
Integrated workflow for analysis of immune enriched spatial proteomic data with IMmuneCite. 2025 Sci Rep
Intestinal epithelial PTPN2 limits pathobiont colonization by immune-directed antimicrobial responses. 2025 Gut Microbes
Intravenous and intracranial GD2-CAR T cells for H3K27M(+) diffuse midline gliomas. 2025 Nature
Large language model agents can use tools to perform clinical calculations. 2025 NPJ Digit Med
LGR4 is essential for maintaining beta-cell homeostasis through suppression of RANK. 2025 Mol Metab
Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction. 2025 bioRxiv
Menthol, a consumer product additive, adversely affects human embryonic stem cells via activation of TRPM8 and TRPA1 channels. 2025 Stem Cells Transl Med
Micropatterning Photoconductive Peptide Assemblies on Stiff and Soft Biomaterial Substrates. 2025 ACS Appl Mater Interfaces
Minimally invasive serial collection of cerebrospinal fluid reveals sex-dependent differences in neuroinflammation in a rat model of mild traumatic brain injury. 2025 Brain Behav Immun
Morphogen-guided neocortical organoids recapitulate regional areal identity and model neurodevelopmental disorder pathology. 2025 bioRxiv
Neuroendocrinology and the Genetics of Obesity. 2025 Endocrinology
Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics. 2025 Nat Commun
On the Feasibility of SERS-Based Monitoring of Drug Loading Efficiency in Exosomes for Targeted Delivery. 2025 Biosensors (Basel)
Overcoming ovarian cancer resistance and evasion to CAR-T cell therapy by harnessing allogeneic CAR-NKT cells. 2025 Med
PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling. 2025 bioRxiv
Probing DNA damage in Rett syndrome neurons uncovers a role for MECP2 regulation of PARP1. 2025 Stem Cell Reports
Proof of concept for brain organoid-on-a-chip to create multiple domains in forebrain organoids. 2025 RSC Adv
Proteasome inhibition enhances oncolytic reovirus therapy in multiple myeloma independently of its direct cytotoxic effects. 2025 J Hematol Oncol
Protocol to study ductal progenitor-like cells from the adult human pancreas using 3D suspension and methylcellulose-based culture systems. 2025 STAR Protoc
PTPN2 Regulates Iron Handling Protein Expression in Inflammatory Bowel Disease Patients and Prevents Iron Deficiency in Mice. 2025 Int J Mol Sci
Rapamycin enhances CAR-T control of HIV replication and reservoir elimination in vivo. 2025 J Clin Invest
Reversible proliferative arrest induced by rapid depletion of RNase MRP. 2025 Nat Commun
Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens. 2025 Cell
Size and Structural Control of Mechanoluminescent ZnS:Mn(2+) Nanocrystals for Optogenetic Neuromodulation. 2025 ACS Nano
Spatial and Single-Cell Transcriptomics Reveal Keratinocytes as Key Players in Vulvar Lichen Sclerosus Pathogenesis. 2025 J Invest Dermatol
Spinal Cord Injury in Real Time: Intra-Operative Ultrasound for Acute Phase Examination in Non-Human Primates. 2025 Brain Sci
Structural and functional analysis of cancer-associated missense variants in the retinoblastoma protein pocket domain. 2025 J Biol Chem
Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis. 2025 Proc Natl Acad Sci U S A
Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development. 2025 Geroscience
The Proteostasis Network is a Therapeutic Target in Acute Myeloid Leukemia. 2025 Blood
The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis. 2025 Gut Microbes
The UCSC Genome Browser database: 2025 update. 2025 Nucleic Acids Res
Therapeutic genetic restoration through allogeneic brain microglia replacement. 2025 Nature
Understanding human embryogenesis by building programmable stem cell-based models. 2025 Trends Cell Biol
Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction. 2025 Nat Commun
VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment. 2025 bioRxiv
Visualizing PIEZO1 localization and activity in hiPSC-derived single cells and organoids with HaloTag technology. 2025 Nat Commun
Wnt/beta-catenin maintains epithelial IL-33 in the colonic stem and progenitor cell niche and drives its induction in colitis. 2025 Mucosal Immunol
A CD38-directed, single-chain T-cell engager targets leukemia stem cells through IFN-gamma-induced CD38 expression. 2024 Blood
A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis. 2024 Elife
A facilitatory role of astrocytes in axonal regeneration after acute and chronic spinal cord injury. 2024 Exp Neurol
A fibroblast-dependent TGF-beta1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis. 2024 J Clin Invest
A framework for N-of-1 trials of individualized gene-targeted therapies for genetic diseases. 2024 Nat Commun
A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS. 2024 Nature
A maternal brain hormone that builds bone. 2024 Nature
A novel high-titer, bifunctional lentiviral vector for autologous hematopoietic stem cell gene therapy of sickle cell disease. 2024 Mol Ther Methods Clin Dev
A Panoramic View of Cell Population Dynamics in Mammalian Aging. 2024 bioRxiv
A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa. 2024 Nat Commun