University of California, Irvine

Awards to the Institution

Program	Investigator	Award Title	Award Value
Patent Assistance Fund Awards	Ronnie Hanecak	CIRM Patent Assistance Fund Application - UCI	$46,155
Conference – The 2020 Grantee Meeting	Daniela Bota	2020 CIRM Grantee Meeting	$176,762
Quest - Discovery Stage Research Projects	Mathew Blurton-Jones	Transplantation of genetically corrected iPSC-microglia for the treatment of Sanfilippo Syndrome (MPSIIIA)	$1,083,379
Early Translational II	Brian Cummings	Neural restricted, FAC-sorted, human neural stem cells to treat traumatic brain injury	$1,517,767
SEED Grant	Thomas Lane	Human Embryonic Stem Cells and Remyelination in a Viral Model of Demyelination	$368,081
Comprehensive Grant	Hans Keirstead	hESC-Derived Motor Neurons For the Treatment of Cervical Spinal Cord Injury	$2,158,445
Early Translational III	Craig Walsh	Multiple Sclerosis therapy: Human Pluripotent Stem Cell-Derived Neural Progenitor Cells	$4,535,005
Shared Labs	Peter Donovan	The University of California: Irvine Regional Human Embryonic Stem Cell Shared Research Laboratory and Stem Cell Techniques Course	$2,107,376
Inception - Discovery Stage Research Projects	Janet Baulch	An exosome-based translational strategy to mitigate Alzheimer’s disease neuropathology	$157,650
Progression Award - Discovery Stage Research Projects	Brian Cummings	Human neural stem cell (hNSC) derived exosomes vs CSC14 hNSCs for the treatment of traumatic brain injury (TBI)	$202,667
Quest - Discovery Stage Research Projects	Michael Demetriou	CAR T cells targeting abnormal N-glycans for the treatment of refractory/metastatic solid cancers	$1,414,800
Early Translational II	Leslie Thompson	A hESc-based Development Candidate for Huntington's Disease	$3,955,038
SEED Grant	Brian Cummings	The Immunological Niche: Effect of immunosuppressant drugs on stem cell proliferation, gene expression, and differentiation in a model of spinal cord injury.	$595,345
Early Translational I	Frank LaFerla	Neural Stem Cells as a Developmental Candidate to Treat Alzheimer Disease	$3,599,997
Disease Team Therapy Development - Research	Henry Klassen	Retinal progenitor cells for treatment of retinitis pigmentosa	$17,144,825
Tools and Technologies III	Mathew Blurton-Jones	Optimizing the differentiation and expansion of microglial progenitors from human pluripotent stem cells for the study and treatment of neurological disease.	$1,147,596
Quest - Discovery Stage Research Projects	Brian Cummings	Identification and characterization of the optimal human neural stem cell line (hNSC) for the treatment of traumatic brain injury (TBI) 2.0.	$1,671,213
Quest - Discovery Stage Research Projects	Mathew Blurton-Jones	Transplantation of Pluripotent Stem Cell Derived Microglia for the Treatment of Adult-onset Leukoencephalopathy (HDLS/ALSP)	$214,668
COMPASS Training Grant	Brian Cummings	Research Mentorship Program in Regenerative Medicine Careers for a Diverse Undergraduate Student Body	$2,729,900
Early Translational II	Henry Klassen	Human retinal progenitor cells as candidate therapy for retinitis pigmentosa	$1,803,768
SEED Grant	Charles Limoli	Using human embryonic stem cells to treat radiation-induced stem cell loss: Benefits vs cancer risk	$593,242
Shared Labs	Peter Donovan	The University of California: Irvine Regional Human Embryonic Stem Cell Shared Research Laboratory and Stem Cell Techniques Course	$3,072,500
Early Translational IV	Magdalene Seiler	Restoring vision by sheet transplants of retinal progenitors and retinal pigment epithelium (RPE) derived from human embryonic stem cells (hESCs)	$3,998,948
Preclinical Development Awards	Leslie Thompson	A hNSC Development Candidate for Huntington’s Disease	$4,951,623
Quest - Discovery Stage Research Projects	Aileen Anderson	Generation and in vitro profiling of neural stem cell lines to predict in vivo efficacy for chronic cervical spinal cord injury.	$1,575,613
Quest - Discovery Stage Research Projects	Robert Hunt	Optimization of a human interneuron cell therapy for traumatic brain injury	$250,000
Alpha Stem Cell Clinics Network Expansion	Daniela Bota	A hub and spoke community model to equitably deliver regenerative medicine therapies to diverse populations across four California counties	$8,000,000
Early Translational II	leif Havton	Repair of Conus Medullaris/Cauda Equina Injury using Human ES Cell-Derived Motor Neurons	$1,527,011
SEED Grant	Frank LaFerla	Development of human ES cell lines as a model system for Alzheimer disease drug discovery	$473,963
Tools and Technologies I	Lisa Flanagan	Novel Separation of Stem Cell Subpopulations	$861,122
Basic Biology V	Lisa Flanagan	Molecular basis of plasma membrane characteristics reflecting stem cell fate potential	$994,108
Conference II	Sidney Golub	Human Research In Times of Controversy: From Stem Cells To Fetal Tissue	$13,562
Conference II	Leslie Thompson	Stem Cells for Huntington’s Disease (HD) International (SC4HDI) Conference	$31,727
Quest - Discovery Stage Research Projects	Munjal Acharya	Stem cell-derived extracellular vesicles to reverse radiation-induced brain injury	$1,064,724
Conference II	Mathew Blurton-Jones	ALSP Community Conference: Insights and Potential of Cell-Based Therapies for the Treatment of Leukodystrophies	$42,500
New Cell Lines	Leslie Thompson	New Cell Lines for Huntington's Disease	$1,302,526
SEED Grant	Vincent Procaccio	Mitochondrial Dysfunction in Embryonic Stem Cells	$245,582
Tools and Technologies I	Orhan NALCIOGLU	A MULTI-MODALITY MOLECULAR IMAGING SYSTEM (MRSPECT) FOR IN VIVO STEM CELL TRACKING	$719,798
Basic Biology V	Peter Donovan	Non-invasive live imaging of stem cell signature metabolic states	$516,366
Conference II	LESLIE Thompson	HD-CARE INAUGURAL SYMPOSIUM	$1,500
Therapeutic Translational Research Projects	Magdalene Seiler	Morphological and functional integration of stem cell derived retina organoid sheets into degenerating retina models	$4,769,039
Research Training Grant	Peter Donovan	CIRM Scholars Comprehensive Research Training Program	$5,000,000
Foundation - Discovery Stage Research Projects	Brian Cummings	Mapping the spatial and temporal responses of hESC-derived microglia to repeat mild closed head injury to identify therapeutic targets and mechanisms	$1,555,140
SEED Grant	Grant MacGregor	Production of Oocytes from Human ES Cells	$385,466
New Faculty II	Edwin Monuki	Mechanisms in Choroid Plexus Epithelial Development	$2,793,395
New Faculty I	Andrew Putnam	A Novel Engineered Niche to Explore the Vasculogenic Potential of Embryonic Stem Cells	$395,764
Major Facilities	Michael Drake	UC Irvine CIRM Institute	$27,156,000
Quest - Discovery Stage Research Projects	Leslie Thompson	hNSC-mediated delivery of ApiCCT1 as a candidate therapeutic for Huntington’s disease	$1,650,263
Late Stage Preclinical Projects	Leslie Thompson	An hESC-derived hNSC Therapeutic for Huntington’s Disease	$5,635,393
Therapeutic Translational Research Projects	Aileen Anderson	A human neural stem cell therapeutic candidate for the treatment of chronic cervical spinal cord injury	$4,950,024
Foundation - Discovery Stage Research Projects	Albert La Spada	Role of ataxin-3 polyadenylation site selection in ALS neuron toxicity and disease pathogenesis	$1,514,416
Basic Biology II	Aileen Anderson	Role of the microenvironment in human iPS and NSC fate and tumorigenesis	$1,256,194
SEED Grant	Michelle Khine	Micro Platform for Controlled Cardiac Myocyte Differentiation	$156,426
Comprehensive Grant	Peter Donovan	Improved hES Cell Growth and Differentiation	$2,381,713
Research Training II	Peter Donovan	UCI-CIRM Research Training Program II	$6,067,550
Disease Team Planning	Henry Klassen	Stem cells for neuroprotection of photoreceptors in retinitis pigmentosa	$23,537
Conference	Michelle Khine	UC Systemwide Bioengineering Symposium	$7,525
Therapeutic Translational Research Projects	Brian Cummings	An optimized human neural stem cell line (hNSC) for the treatment of traumatic brain injury (TBI)	$4,804,737
Conference II	Olga Razorenova	UCI Stem Cell Research Center 9th Annual Stem Cell Science Symposium	$8,366
Late Stage Preclinical Projects	Kyriacos Athanasiou	Treatment of the TMJ disc complex	$6,000,000
Basic Biology II	Marian Waterman	TCF-3: A Wnt Pathway Effector and Nanog Regulator in Pluripotent Stem Cell Self-Renewal	$1,259,879
SEED Grant	Kyoko Yokomori	Derivation and characterization of human ES cells from FSHD embryos	$607,200
Comprehensive Grant	Douglas Wallace	The Dangers of Mitochondrial DNA Heteroplasmy in Stem Cells Created by Therapeutic Cloning	$1,790,133
Training Grant I-1	Peter Bryant	Stem Cell Research Training Grant	$1,935,487
Disease Team Planning	Leslie Thompson	Huntington's Disease Team	$41,953
Conference	Peter Donovan	Systems Biology of Stem Cells	$25,000
			Total: $159,037,452.00