An exosome-based translational strategy to mitigate Alzheimer’s disease neuropathology

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Grant Award Details

Grant Type:
Inception – Discovery Stage Research Projects
Grant Number:
DISC1-10079
Investigator(s):
Name:
Janet E Baulch
Institution:
University of California, Irvine
Type:
PI

Disease Focus:
Alzheimer's Disease, Neurological Disorders
Human Stem Cell Use:
Embryonic Stem Cell
Award Value:
$157,650
Status:
Closed

Progress Reports

Reporting Period:
Year 1

Grant Application Details

Application Title:

An exosome-based translational strategy to mitigate Alzheimer’s disease neuropathology

Public Abstract:
Research Objective

These studies will determine whether stem cell derived exosomes (nano-scale vesicles) can be used to treat the symptoms of Alzheimer’s disease (AD).

Impact

Our stem cell-derived exosome therapy will provide a viable approach to ameliorate the relentless progression of AD that severely impacts quality of life for millions of patients and their families.

Major Proposed Activities

  • Evaluate whether exosome therapy can reduce the symptoms of early stage AD including anxiety, depression, and learning and memory.
  • Evaluate whether exosome therapy can reduce the symptoms of advanced stage AD including anxiety, depression, and learning and memory.
  • Determine whether exosome therapy can slow the appearance of AD related changes typically observed in the early stage AD brain.
  • Determine whether exosome therapy can reduce the appearance of AD related changes typically observed in the advanced stage AD brain.
Statement of Benefit to California:
In the US, California has the most cases of AD, a burden on patients, their families, and the health care system. As such, AD is an unmet medical need that requires new therapies to improve disease management. This project tests a transformational idea—human stem cell derived exosome therapy. These studies will identify a novel stem cell-based strategy and a viable approach to impede the progression of AD and it’s symptoms that severely impact quality of life for patients and their families.

Publications