Grant Award Details
- this is a training grant. appropriate courses, workshops, journal clubs etc. have been and will be expected to be provided to trainees.
Progress Reports
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Grant Application Details
- Interdisciplinary Stem Cell Training Program
This proposal describes a Type I stem cell training program including a School of Medicine, a Division of Biological Sciences, a School of Pharmacy and Pharmaceutical Sciences, and a School of Engineering. This program is designed to provide interdisciplinary training in stem cell biology and medicine by taking advantage of the unique interdisciplinary and inter-institutional environment. A major goal is to train a cadre of young basic and clinical scientists and engineers in the use of quantitative and engineering approaches from the physical sciences such as chemistry, computation, and materials science to make novel discoveries in basic and clinical biomedicine. Basic and clinical science and engineering trainees who complete our program will be ideally suited for future careers as academic or industrial scientists investigating stem cell biology and medicine, or using stem cell based methods to develop new therapeutic approaches to human diseases. Our approach will be to build on each trainee’s specialized foundation of basic or clinical knowledge and provide: •Rigorous education in the principles and applications of embryonic and adult stem cell biology from humans and model organisms •Research training in physical, computational, and engineering methods that can be used to harness stem cells to attack problems of basic and clinical science and their uses to develop new understanding and new therapies •Education in the problems and outlooks associated with the ethical, legal, social, and economic issues associated with stem cell biology Our training program will also serve as a catalyst for the integration of our expanding stem cell biology research and training efforts. Our training is structured to take advantage of the [REDACTED] scientific and medical community by engaging in collaboration with three other institutions. We are requesting financial support for 16 trainees (6 graduate, 5 postdoctoral, 5 clinical fellow).
Benefit of this Program to California This program will benefit the people and the state of California by providing high-quality training in the scientific, clinical, social, and ethical aspects of stem cell research to the scientists and clinicians who will develop and apply future therapies in this rapidly emerging field.
Publications
- Mol Cell (2011) Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. (PubMed: 22099302)
- Nature (2011) Somatic coding mutations in human induced pluripotent stem cells. (PubMed: 21368825)
- Proc Natl Acad Sci U S A (2011) In vivo demonstration that {alpha}-synuclein oligomers are toxic. (PubMed: 21325059)
- Mol Cell (2011) Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells. (PubMed: 21514197)
- Genes Dev (2011) Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. (PubMed: 21357675)
- Genome Med (2011) Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges. (PubMed: 21867573)
- Tissue Eng Part A (2011) Decellularized Porcine Brain Matrix for Cell Culture and Tissue Engineering Scaffolds. (PubMed: 21883047)
- Proc Natl Acad Sci U S A (2011) Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy. (PubMed: 21464322)
- Mol Cell (2011) Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. (PubMed: 21596314)
- PLoS One (2011) Sox9-haploinsufficiency causes glucose intolerance in mice. (PubMed: 21829703)
- Genome Res (2010) Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. (PubMed: 20418490)
- PLoS One (2010) Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. (PubMed: 20885963)
- Biomacromolecules (2010) Heparin mimicking polymer promotes myogenic differentiation of muscle progenitor cells. (PubMed: 21058638)
- J Clin Invest (2010) T-cadherin is critical for adiponectin-mediated cardioprotection in mice. (PubMed: 21041950)
- Am J Hum Genet (2010) Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome. (PubMed: 20137777)
- Wiley Interdiscip Rev Syst Biol Med (2010) Human cardiomyogenesis and the need for systems biology analysis. (PubMed: 21197666)
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