Grant Award Details
- this is a training grant. appropriate courses, workshops, journal clubs etc. have been and will be expected to be provided to trainees.
Progress Reports
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Grant Application Details
- Interdisciplinary Stem Cell Training Program
This proposal describes a Type I stem cell training program including a School of Medicine, a Division of Biological Sciences, a School of Pharmacy and Pharmaceutical Sciences, and a School of Engineering. This program is designed to provide interdisciplinary training in stem cell biology and medicine by taking advantage of the unique interdisciplinary and inter-institutional environment. A major goal is to train a cadre of young basic and clinical scientists and engineers in the use of quantitative and engineering approaches from the physical sciences such as chemistry, computation, and materials science to make novel discoveries in basic and clinical biomedicine. Basic and clinical science and engineering trainees who complete our program will be ideally suited for future careers as academic or industrial scientists investigating stem cell biology and medicine, or using stem cell based methods to develop new therapeutic approaches to human diseases. Our approach will be to build on each trainee’s specialized foundation of basic or clinical knowledge and provide: •Rigorous education in the principles and applications of embryonic and adult stem cell biology from humans and model organisms •Research training in physical, computational, and engineering methods that can be used to harness stem cells to attack problems of basic and clinical science and their uses to develop new understanding and new therapies •Education in the problems and outlooks associated with the ethical, legal, social, and economic issues associated with stem cell biology Our training program will also serve as a catalyst for the integration of our expanding stem cell biology research and training efforts. Our training is structured to take advantage of the [REDACTED] scientific and medical community by engaging in collaboration with three other institutions. We are requesting financial support for 16 trainees (6 graduate, 5 postdoctoral, 5 clinical fellow).
Benefit of this Program to California This program will benefit the people and the state of California by providing high-quality training in the scientific, clinical, social, and ethical aspects of stem cell research to the scientists and clinicians who will develop and apply future therapies in this rapidly emerging field.
Publications
- Nat Commun (2016) High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo. (PubMed: 27425143)
- EMBO J (2015) Forward engineering neuronal diversity using direct reprogramming. (PubMed: 25908841)
- Nat Neurosci (2015) Selective conversion of fibroblasts into peripheral sensory neurons. (PubMed: 25420069)
- Elife (2015) Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy. (PubMed: 26308581)
- Neurochem Res (2015) Effects of ATP and NGF on Proliferation and Migration of Neural Precursor Cells. (PubMed: 26233465)
- Cell Transplant (2015) Roles of kinins in the nervous system. (PubMed: 25839228)
- Neurochem Res (2015) Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation. (PubMed: 25758980)
- Placenta (2015) MTA3 regulates differentiation of human cytotrophoblast stem cells. (PubMed: 26198267)
- Annu Rev Cell Dev Biol (2015) Musashi signaling in stem cells and cancer. (PubMed: 26566113)
- Mol Psychiatry (2015) Altered neuronal network and rescue in a human MECP2 duplication model. (PubMed: 26347316)
- Mol Cell Biol (2014) TET2 plays an essential role in erythropoiesis by regulating lineage-specific genes via DNA oxidative demethylation in a zebrafish model. (PubMed: 24396069)
- Sci Rep (2014) Technical Variations in Low-Input RNA-seq Methodologies. (PubMed: 24419370)
- Proc Natl Acad Sci U S A (2014) The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells. (PubMed: 24474766)
- Nat Genet (2014) Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia. (PubMed: 24487275)
- Nat Neurosci (2014) Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. (PubMed: 25108912)
- Proc Natl Acad Sci U S A (2013) Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. (PubMed: 23324740)
- Nat Commun (2013) Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. (PubMed: 23340422)
- PLoS One (2013) Use of a molecular genetic platform technology to produce human wnt proteins reveals distinct local and distal signaling abilities. (PubMed: 23516471)
- Sci Rep (2013) Quantitative Transcriptomics using Designed Primer-based Amplification. (PubMed: 23624976)
- Stem Cells Dev (2013) Hypoxia and trophoblast differentiation: a key role for PPARgamma (PubMed: 23767827)
- PLoS One (2013) Whole transcriptome sequencing enables discovery and analysis of viruses in archived primary central nervous system lymphomas. (PubMed: 24023918)
- Cell Stem Cell (2013) Efficient generation of human iPSCs by a synthetic self-replicative RNA. (PubMed: 23910086)
- PLoS One (2013) Encodes Two Isoforms with Distinct Functions in Cancers. (PubMed: 24260410)
- Cell (2013) Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. (PubMed: 23602152)
- Cell (2013) AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder. (PubMed: 23911318)