Publications by Grantees

CIRM funding supported the following publications. Click on the publication title for a brief summary of the research and for more information:

Title Year Journal
Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. 2014 Mol Psychiatry
Polyglutamine Disease Modeling: Epitope Based Screen for Homologous Recombination using CRISPR/Cas9 System. 2014 PLoS Curr
Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. 2014 Nat Neurosci
Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. 2014 Proc Natl Acad Sci U S A
Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway. 2014 Cell Rep
Potential for Cell Therapy in Parkinson’s Disease Using Genetically-Programmed Human Embryonic Stem Cell-Derived Neural Progenitor Cells. 2014 J Comp Neurol
Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. 2014 Proc Natl Acad Sci U S A
Primary Cilia Integrate Hedgehog and Wnt Signaling during Tooth Development. 2014 J Dent Res
Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. 2014 Cell Stem Cell
Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies. 2014 Expert Rev Neurother
Protein post-translational modifications and regulation of pluripotency in human stem cells. 2014 Cell Res
Ptch2 mediates the Shh response in Ptch1-/- cells. 2014 Development
Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. 2014 Nat Immunol
Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex. 2014 Nature
RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. 2014 Nat Genet
Rapid and Efficient Conversion of Integration-Free Human Induced Pluripotent Stem Cells to GMP-Grade Culture Conditions. 2014 PLoS One
Recombinase-Mediated Reprogramming and Dystrophin Gene Addition in mdx Mouse Induced Pluripotent Stem Cells. 2014 PLoS One
Regenerative medicine: is this the biggest change in surgery? 2014 Semin Pediatr Surg
Regulation of iPS Cell Induction by Wnt/beta-catenin Signaling. 2014 J Biol Chem
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. 2014 Nat Med
Reliable Generation of Induced Pluripotent Stem Cells From Human Lymphoblastoid Cell Lines. 2014 Stem Cells Transl Med
Reorganization of enhancer patterns in transition from naive to primed pluripotency. 2014 Cell Stem Cell
Replication of Mycobacterium tuberculosis in retinal pigment epithelium. 2014 JAMA Ophthalmol
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. 2014 Nature
Reprogramming by lineage specifiers: blurring the lines between pluripotency and differentiation. 2014 Curr Opin Genet Dev
Reprogramming Human Retinal Pigmented Epithelial Cells to Neurons Using Recombinant Proteins. 2014 Stem Cells Transl Med
Research capacity. Enabling the genomic revolution in Africa. 2014 Science
ROCK Inhibition Extends Passage of Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium. 2014 Stem Cells Transl Med
Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells. 2014 Nat Commun
Role of BRCA1 in brain development. 2014 Proc Natl Acad Sci U S A
Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. 2014 Neuron
Serine integrase chimeras with activity in E. coli and HeLa cells. 2014 Biol Open
Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes. 2014 Endocrinology
Shaking up the salt and pepper: origins of cellular heterogeneity in the inner cell mass of the blastocyst. 2014 EMBO J
Signaling pathways in induced naive pluripotency. 2014 Curr Opin Genet Dev
Single-cell gene expression profiles define self-renewing, pluripotent, and lineage primed States of human pluripotent stem cells. 2014 Stem Cell Reports
Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development. 2014 Cell
Single-cell western blotting. 2014 Nat Methods
Single-molecule super-resolution light-sheet microscopy. 2014 Chemphyschem
SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling. 2014 Stem Cell Reports
Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4. 2014 Cell Rep
Somatic correction of junctional epidermolysis bullosa by a highly recombinogenic AAV variant. 2014 Mol Ther
Spatiotemporally different origins of NG2 progenitors produce cortical interneurons versus glia in the mammalian forebrain. 2014 Proc Natl Acad Sci U S A
Specialized mouse embryonic stem cells for studying vascular development. 2014 Stem Cells Cloning
Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression. 2014 FASEB J
Splicing factor TRA2B is required for neural progenitor survival. 2014 J Comp Neurol
Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo. 2014 Development
sRNA-seq analysis of human embryonic stem cells and definitive endoderm reveal differentially expressed microRNAs and novel isomiRs with distinct targets. 2014 Stem Cells
STAT3 Phosphorylation at Tyrosine 705 and Serine 727 Differentially Regulates Mouse ESC Fates. 2014 Stem Cells
STAT3 signaling controls satellite cell expansion and skeletal muscle repair. 2014 Nat Med
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