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Multiple Sclerosis therapy: Human Pluripotent Stem Cell-Derived Neural Progenitor Cells

  • Post author:
  • Post published:May 21, 2025
  • Post category:

Multiple Sclerosis (MS) is a disease of the central nervous system (CNS) caused by inflammation and loss of cells that produce myelin, which normally insulates and protects nerve cells. MS…

Continue ReadingMultiple Sclerosis therapy: Human Pluripotent Stem Cell-Derived Neural Progenitor Cells

Molecules to Correct Aberrant RNA Signature in Human Diseased Neurons

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  • Post published:May 21, 2025
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Approximately 5,600 people in the U.S. are diagnosed with ALS each year. The incidence of ALS is two per 100,000 people, and it is estimated that as many as 30,000…

Continue ReadingMolecules to Correct Aberrant RNA Signature in Human Diseased Neurons

Use of human iPS cells to study spinal muscular atrophy

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  • Post published:May 21, 2025
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Spinal muscular atrophy (SMA) is one of the most common autosomal recessive disorders that cause infant mortality. SMA is caused by loss of the Survival of Motor Neuron (SMN) protein,…

Continue ReadingUse of human iPS cells to study spinal muscular atrophy

Correlated time-lapse imaging and single cell molecular analysis of human embryo development

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  • Post published:May 21, 2025
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We understand little about human development especially at the earliest stages. Yet human developmental biology is very important to stem cell biology and regenerative medicine for two reasons: 1) Understanding…

Continue ReadingCorrelated time-lapse imaging and single cell molecular analysis of human embryo development

Discovery of mechanisms that control epigenetic states in human reprogramming and pluripotent cells

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  • Post published:May 21, 2025
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The CIRM Basic Biology Award III was developed to support basic research that enables the realization of the full potential of human stem cells and reprogrammed cells for therapies and…

Continue ReadingDiscovery of mechanisms that control epigenetic states in human reprogramming and pluripotent cells

Investigation of synaptic defects in autism using patient-derived induced pluripotent stem cells

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  • Post published:May 21, 2025
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Autism spectrum disorders (ASD) are a group of neurodevelopmental diseases that occur in as many as 1 in 150 children in the United States. Three hallmarks of autism are dysfunctional…

Continue ReadingInvestigation of synaptic defects in autism using patient-derived induced pluripotent stem cells

Functional characterization of mutational load in nuclear reprogramming and differentiation

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  • Post published:May 21, 2025
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One of the most potentially powerful aspects of regenerative medicine is stem cell therapy. In this therapy, healthy tissues derived from stem cells will be implanted into patients with damaged…

Continue ReadingFunctional characterization of mutational load in nuclear reprogramming and differentiation

Triplet Repeat Instability in Human iPSCs

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  • Post published:May 21, 2025
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Over twenty human genetic diseases are caused by expansion of simple DNA sequences composed of repeats of three nucleotides (such as CAG, CTG, CGG and GAA) within essential genes. These…

Continue ReadingTriplet Repeat Instability in Human iPSCs

Elucidating Molecular Basis of Hypertrophic Cardiomyopathy with Human Induced Pluripotent Stem Cells

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  • Post published:May 21, 2025
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Familial hypertrophic cardiomyopathy (HCM) is the leading cause of sudden cardiac death in young people, including trained athletes, and is the most common inherited heart defect. Until now, studies in…

Continue ReadingElucidating Molecular Basis of Hypertrophic Cardiomyopathy with Human Induced Pluripotent Stem Cells

Characterization and Engineering of the Cardiac Stem Cell Niche

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  • Post published:May 21, 2025
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Despite therapeutic advances, cardiovascular disease remains a leading cause of mortality and morbidity in both California and Europe. New insights into disease pathology, models to expedite in vitro testing and…

Continue ReadingCharacterization and Engineering of the Cardiac Stem Cell Niche
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