Human Stem Cell Use: iPS Cell
Thymus based tolerance to stem cell therapies
This proposal focuses on the role of the immune system in transplantation of derivatives of human pluripotent stem cells (hPSCs). A critical roadblock to successful cell replacement therapies, no matter what the disease or injury, is the fact that the immune system’s main function is to prevent the introduction of foreign substances into our bodies. […]
Stem cell differentiation to thymic epithelium for inducing tolerance to stem cells
The thymus is an organ that plays a key role in controlling immune responses and immune tolerance. The thymus promotes immune tolerance by deleting and removing self-reactive T cells from the immune system. In addition, the thymus also helps drive the production of important suppressor T cell populations like regulatory T cells that also control […]
Discovery of adhesion ligands for pluripotent human stem cells
We have assembled a team of investigators with complementary expertise in applying the state-of-the-art “one-bead-one-compound” (OBOC) combinatorial library methods to identify synthetic chemical molecules that bind to unique receptors (protein molecules) on the surface of human embryonic stem cells and induced pluripotent stem cells. In this technology, stem cells will be mixed with huge number […]
The Stem Cell Matrix: a map of the molecular pathways that define pluripotent cells
Human embryonic stem cells (hESC) are being considered for a wide range of research and therapeutic uses. Cell therapy is the most challenging of the potential clinical applications and its success will depend on the ability to guide differentiation of hESC into clinically useful cell types. The ideal cell types would possess three features: the […]
The University of California San Francisco Shared Research and Teaching Laboratory: a Non-Federal Human Embryonic Stem Cell Resource for the Bay Area Community
The University of California, San Francisco (UCSF) has a long history of making innovative discoveries that change the way scientists and clinicians think about disease processes and their approaches to finding cures. Accordingly, researchers at this institution were quick to appreciate the enormous promise of human embryonic stem cells (hESCs) as research tools for understanding […]
Enhancing Facilities for Genetic Manipulation and Engineering of Human Embryonic Stem Cells at UCSD
Human embryonic stem cell (hESC) research promises to be of fundamental importance in the study and treatment of various human diseases, including cancer, neurodegenerative disorders and organ failure. In recent years we have made great strides in advancing hESC research as documented by the large number of successful, high-impact laboratories and breadth of research projects […]
The UCSB Laboratory for Stem Cell Biology and Engineering
Regenerative medicine is an emerging area that will only realize its great potential through novel collaborative research approaches, and the University of California at Santa Barbara (UCSB) is well positioned to make significant contributions by leveraging fundamental biomedical research efforts with enabling technologies in materials, microfluidics and bioengineering. This proposal details plans for the development […]
The Stanford University Center for Human Embryonic Stem Cell Research and Education
The goal of this proposal is to establish a premiere center for human embryonic stem cell (hESC) research and education in the state of California. Our center builds on the established excellence of faculty with research organized into four thematic areas: Human embryology, derivation of hESC lines, including disease-specific lines, and SCNT, Cell fate specification […]
A Stem Cell Core Facility for Studying Human Embryonic Stem Cell Differentiation
This application proposes to develop a Stem Cell Core Facility of ~1700 square feet to support the use of human embryonic stem cells (hESC) for a growing consortium of stem cell scientists at the home institution as well as neighboring institutions. The facility will be built and managed so as to allow use of non-NIH-approved […]
CIRM Shared Research Laboratories
Our plan is to establish a ~ 4,700 sq. ft. shared research laboratory dedicated to the experimental manipulation and ultimate clinical application of human embryonic stem cells (hESC). This Shared Research Laboratory (SRL) is centrally located on the main campus. The SRL will be used by researchers focused on understanding how hESCs are induced to […]