Establishment of a novel approach to systematically study the dynamic organization of protein complexes in stem cells

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Research Objective We focus on hiPSCs pluripotency and neurodifferentiation to develop a novel framework to allow simultaneous identification of multiple interactions between proteins and between proteins and the genome Impact…

Continue ReadingEstablishment of a novel approach to systematically study the dynamic organization of protein complexes in stem cells

Development of a stem-cell based approach to interpret global effects of genetic variants contributing to neurodevelopmental disease risk

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Research Objective We are developing a strategy to characterize the disease-relevance of hundreds of mutations across diverse genetic backgrounds using stem cells Impact Understanding how mutations impact cellular function can…

Continue ReadingDevelopment of a stem-cell based approach to interpret global effects of genetic variants contributing to neurodevelopmental disease risk

Stem cell-based rapid identification of SARS-CoV-2 T cell epitopes and T cell receptors for therapeutic use

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Research Objective We will identify SAR-CoV-2 T cell epitopes for vaccine development and specific TCRs for adoptive T cell therapy using a stem cell-based platform to generate specialized dendritic cells…

Continue ReadingStem cell-based rapid identification of SARS-CoV-2 T cell epitopes and T cell receptors for therapeutic use