Project Objective: Tool/Resources/Bottleneck

Creating A Collaborative California Cell and Gene Therapy Manufacturing Network

The need for cell and gene therapy product manufacturing will be ever increasing over the next decade, and several new GMP facilities are coming online. We believe it is important to continue to advance the processes and to share our accumulated knowledge for early and late-stage clinical trials. Through the proposal a partnership with other […]

Scalable Expansion for Stem Cell-derived Therapies

Succesful completion of this proposal will identify a scalable process that supports iPSC expansion, T cell expansion, and cardiomyocyte maturation / expansion that is ready for validation in a large scale bioreactor (25 – 2000L) and tech transfer to GMP manufacturing. Creating low cost scalable allogeneic therapies democratizes cell and gene therapy modalities, allowing for […]

Enhancing California’s Manufacturing of Leading-Edge Cell & Gene Therapies

We will implement a new staffing model, training regimen, electronic quality management system, and outreach activities to overcome current bottlenecks and provide the foundation for manufacturing the pipeline of cell and gene therapies under development to bring treatments and cures to patients. This project tackles current bottlenecks in manufacturing for cell and gene therapies and […]

Open Manufacturing Network for Cell and Gene Therapies

This project will establish an open-source network to share new cellular engineering platforms across manufacturing facilities; expand our non-viral engineering approaches to improve product safety and efficacy; and formalize our GMP training programs for students, staff, and leadership positions. This project will implement new non-viral engineering platforms to improve cell therapy safety and efficacy, and […]

Advancing Cell Therapy Manufacturing Through Collaboration

The project aims to provide tools & strategies to improve cell therapy manufacturing through collaborations, increase availability of viral vectors, train & educate underrepresented students, standardize data collection in academic GMP facilities, reduce costs and increase accessibility. Our proposal is driven by a deep passion for improving the lives of Californians and advancing the field […]

Laboratory for Cell and Gene Medicine: A partner in the California Cell and Gene Therapy Manufacturing Network

The Stanford LCGM supports process development and manufacturing for investigator initiated and select industry partner clinical trials. The objective of our proposal is to complete our project plan and enhance the LCGM value proposition positioning us competitively for the phase two funding period. A major roadblock in stem cell therapies is confirming efficacy in patients. […]

A comprehensive biomanufacturing center solving bottlenecks in cell and gene therapy manufacturing to accelerate new therapies for California patients

We aim to considerably expand access for all Californians to outstanding cell and gene therapy treatments for multiple patients. With operational enhancements to develop diverse talent from underserved communities, our GMP facility will advance all aspects of biomanufacturing within the network. As part of the Cell and Gene Therapy (CGT) Manufacturing Network, we will bring […]

The UCI GMP Cell and Gene Therapy Manufacturing Facility

To contribute to a network that will de-risk pathways to commercialization for cell and gene therapies and develop a diverse and skilled manufacturing workforce in California, we propose to develop and implement several key activities to meet these goals over the two years of this project proposal. This project will have a significant public impact […]

UCSD Advanced Cell Therapy Laboratory

The project plan outlines key operational enhancements, development of specialization areas, and support for new workforce development initiatives that will enable our GMP cell manufacturing facility be a key component of the new CIRM Cell and Gene Therapy Manufacturing Network. Support for this project will enable our facility to expand our capabilities and workforce development […]

An interactive data resource for hypothesis testing in stem cell single-cell gene expression and validation of the results with brain organoids

Research Objective We are building a "virtual molecular microscope" where anyone can quickly visualize a very recent, high-throughput molecular assay, single-cell RNA-seq and spatial gene expression studies Impact Currently, a lot of data has been published, hundreds of datasets on the cerebral cortex alone, but it takes hours to convert the datasets and look at […]

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