Project Objective: Tool/Resources/Bottleneck
A Center for Stem Cell Disease Modeling and Therapeutics
The goal of this project is to support the discovery and evaluation of novel therapeutics using stem cell-based models and drug and CRISPR screening. The facility will provide California researchers access to tools, technologies, and resources for regenerative medicine research. This project benefits California by helping accelerate research to find cures for major diseases of […]
CIRM ASCEND Center – Advancing Stem Cell Education and Novel Discoveries
The proposed CIRM ASCEND Center provides cutting-edge organoid-based services, offering consultation, optimized protocols, and genomic analysis. We also offer comprehensive training, workshops, and access to data, empowering researchers across California to excel in stem cell and organoid research. Our CIRM ASCEND Center benefits Californians by advancing regenerative medicine and healthcare. The Center’s services and training […]
Shared Resources Laboratories to Enhance In Vitro Stem Cell Modeling and Training
Our broad objective is to expand access to equipment, services, and training within our areas of excellence. Through knowledge sharing and collaboration, we aim to add value to the CIRM SRL network. We seek to build on our historical success and foster excellence in California stem cell research. The SRL will provide access to specialized […]
A modular automation approach to stem cell modeling to increase throughput, reproducibility and access
This project enhances stem cell access, scalability, and collaboration. It offers characterized hPSC lines, CRISPR editing, and differentiation on automated platforms accelerating progress in biology, disease research, and regenerative medicine. The project benefits California by advancing regenerative medicine through diverse hPSC lines, potentially leading to novel treatments and addressing health disparities. It offers educational opportunities […]
Stem Cell-based Disease Modeling Shared Resource Laboratory
Our Shared Resource Laboratory will expand access to stem cell-derived models to support research and educational programs with two main goals: democratize access to state-of-the-art models and technology among a diverse scientific community and catalyze innovation in regenerative medicine. This Shared Resource Laboratory will expand access to stem cell-derived models to regions of Southern California […]
Creating A Collaborative California Cell and Gene Therapy Manufacturing Network
The need for cell and gene therapy product manufacturing will be ever increasing over the next decade, and several new GMP facilities are coming online. We believe it is important to continue to advance the processes and to share our accumulated knowledge for early and late-stage clinical trials. Through the proposal a partnership with other […]
Scalable Expansion for Stem Cell-derived Therapies
Succesful completion of this proposal will identify a scalable process that supports iPSC expansion, T cell expansion, and cardiomyocyte maturation / expansion that is ready for validation in a large scale bioreactor (25 – 2000L) and tech transfer to GMP manufacturing. Creating low cost scalable allogeneic therapies democratizes cell and gene therapy modalities, allowing for […]
Enhancing California’s Manufacturing of Leading-Edge Cell & Gene Therapies
We will implement a new staffing model, training regimen, electronic quality management system, and outreach activities to overcome current bottlenecks and provide the foundation for manufacturing the pipeline of cell and gene therapies under development to bring treatments and cures to patients. This project tackles current bottlenecks in manufacturing for cell and gene therapies and […]
Open Manufacturing Network for Cell and Gene Therapies
This project will establish an open-source network to share new cellular engineering platforms across manufacturing facilities; expand our non-viral engineering approaches to improve product safety and efficacy; and formalize our GMP training programs for students, staff, and leadership positions. This project will implement new non-viral engineering platforms to improve cell therapy safety and efficacy, and […]
Advancing Cell Therapy Manufacturing Through Collaboration
The project aims to provide tools & strategies to improve cell therapy manufacturing through collaborations, increase availability of viral vectors, train & educate underrepresented students, standardize data collection in academic GMP facilities, reduce costs and increase accessibility. Our proposal is driven by a deep passion for improving the lives of Californians and advancing the field […]