Grant Award Details

Optimization of a human interneuron cell therapy for traumatic brain injury
Grant Number: 
DISC2-12164
Investigator: 
Type: 
PI
Disease Focus: 
Neurological Disorders
Traumatic Brain Injury
Human Stem Cell Use: 
iPS Cell
Award Value: 
$250,000
Status: 
Pre-Active

Grant Application Details

Application Title: 
  • Optimization of a human interneuron cell therapy for traumatic brain injury
Public Abstract: 

Research Objective

A cell therapy product comprised of inhibitory neurons that can migrate, integrate and restore neurologic function after traumatic brain injury.

Impact

Traumatic brain injury

Major Proposed Activities

  • Examine the most effective dose and safety profile of human iPSC-derived MGE cells grafted into rodent hippocampus.
  • Determine whether human iPSC-derived MGE cells mature into appropriate cortical interneurons in the traumatically injured brain
  • Evaluate the effect of human GABA neurons on synaptic activity in the injured brain
  • Evaluate the therapeutic potential of human-derived interneurons
Statement of Benefit to California: 

Nearly 6 million Americans - including 700,000 Californians - live with permanent physical or mental health problems resulting from a traumatic brain injury, but there are no treatments. We propose studies to create a cell therapy product that is capable of restoring neurologic function to these patients.