Optimization of a human interneuron cell therapy for traumatic brain injury
Grant Award Details
Grant Type:
Grant Number:
DISC2-12164
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$240,000
Status:
Closed
Progress Reports
Reporting Period:
Year 1
Grant Application Details
Application Title:
Optimization of a human interneuron cell therapy for traumatic brain injury
Public Abstract:
Research Objective
A cell therapy product comprised of inhibitory neurons that can migrate, integrate and restore neurologic function after traumatic brain injury.
Impact
Traumatic brain injury
Major Proposed Activities
A cell therapy product comprised of inhibitory neurons that can migrate, integrate and restore neurologic function after traumatic brain injury.
Impact
Traumatic brain injury
Major Proposed Activities
- Examine the most effective dose and safety profile of human iPSC-derived MGE cells grafted into rodent hippocampus.
- Determine whether human iPSC-derived MGE cells mature into appropriate cortical interneurons in the traumatically injured brain
- Evaluate the effect of human GABA neurons on synaptic activity in the injured brain
- Evaluate the therapeutic potential of human-derived interneurons
Statement of Benefit to California:
Nearly 6 million Americans - including 700,000 Californians - live with permanent physical or mental health problems resulting from a traumatic brain injury, but there are no treatments. We propose studies to create a cell therapy product that is capable of restoring neurologic function to these patients.
