Human neural stem cell (hNSC) derived exosomes vs CSC14 hNSCs for the treatment of traumatic brain injury (TBI)

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Grant Award Details

Grant Type:
Progression Award – Discovery Stage Research Projects
Grant Number:
DISC2P-12150
Investigator(s):
Name:
Dr. Brian J. Cummings
Institution:
University of California, Irvine
Type:
PI

Disease Focus:
Neurological Disorders, Traumatic Brain Injury
Human Stem Cell Use:
Embryonic Stem Cell
Award Value:
$202,667
Status:
Closed

Progress Reports

Reporting Period:
18 months
Reporting Period:
Post Project Allowable Costs

Grant Application Details

Application Title:

Human neural stem cell (hNSC) derived exosomes vs CSC14 hNSCs for the treatment of traumatic brain injury (TBI)

Public Abstract:
Research Objective

To test of exosomes (a tiny vesicle produced by stem cells) can be used to treat brain injuries rather than having to use the entire cell.

Impact

Not having to transplant whole cells would simplify the surgical procedure, avoid the need for immunosuppressant drugs, and increase the safety of using stem cells.

Major Proposed Activities

["Transplantation of Shef6 derived exosomes into an animal model of traumatic brain injury.", "Transplantation of CSC14 derived hNSCs into an animal model of traumatic brain injury."]
Statement of Benefit to California:
If successful, treatment of TBI with embryonic stem cell derived/human neural stem derived exosomes would alleviate the need for long term immmunosuppression - which would greatly benefit individuals with TBI. Were CSC14 derived hNSCSs (a different starting source material) found to also be efficacious, this would simplify the manufacture and scale-up of a treatment for TBI and avoid concerns about cells from the UK (Shef6) potentially harboring prions.

Publications