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Discovering Potent Molecules with Human ESCs to Treat Heart Disease

  • Post author:
  • Post published:June 30, 2025
  • Post category:

This work is directly relevant to human embryonic stem cell (hESC) research because it brings new ideas about novel compounds to affect cardiomyogenesis. The work addresses an urgent need to…

Continue ReadingDiscovering Potent Molecules with Human ESCs to Treat Heart Disease

Autologous cardiac-derived cells for advanced ischemic cardiomyopathy

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  • Post published:June 30, 2025
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The adult human heart contains small numbers of cardiac stem cells that are able to partially repair the heart following a heart attack or throughout the course of progressive heart…

Continue ReadingAutologous cardiac-derived cells for advanced ischemic cardiomyopathy

Human Cardiovascular Progenitors, their Niches and Control of Self-renewal and Cell Fate

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  • Post published:June 30, 2025
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For the millions of Americans who are born with or develop heart disease, stem cell research offers the first hope of reversing or repairing heart muscle damage. Thus, early reports…

Continue ReadingHuman Cardiovascular Progenitors, their Niches and Control of Self-renewal and Cell Fate

A Center for Stem Cell Disease Modeling and Therapeutics

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  • Post published:June 29, 2025
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The goal of this project is to support the discovery and evaluation of novel therapeutics using stem cell-based models and drug and CRISPR screening. The facility will provide California researchers…

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Stem Cell-based Disease Modeling Shared Resource Laboratory

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  • Post published:June 29, 2025
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Our Shared Resource Laboratory will expand access to stem cell-derived models to support research and educational programs with two main goals: democratize access to state-of-the-art models and technology among a…

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Mapping and modeling endothelial cell fate decisions for pulmonary arterial hypertension

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  • Post published:June 29, 2025
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Research Objective We will build a foundational model and experimental platform to catalog all genes that promote and protect against PAH, with the potential to extend to many other developmental…

Continue ReadingMapping and modeling endothelial cell fate decisions for pulmonary arterial hypertension

Drug Discovery for Dilated Cardiomyopathy using Patient-Derived Human iPSCs

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  • Post published:June 29, 2025
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Research Objective Greenstone Biosciences will use patient-derived stem cells to discover safe and effective drugs for cardiovascular disease. Impact The use of patient-derived stem cells to discover novel drug targets…

Continue ReadingDrug Discovery for Dilated Cardiomyopathy using Patient-Derived Human iPSCs

Modulating cardiac myosin heavy chain isoform expression for treating cardiomyopathies

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  • Post published:June 29, 2025
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Research Objective To discover CRISPR-based genetic strategies that will directly and therapeutically modify cardiac myosin heavy chain isoform expression to treat HF and cardiomyopathies. Impact Heart Failure and Cardiomyopathies Major…

Continue ReadingModulating cardiac myosin heavy chain isoform expression for treating cardiomyopathies

RNA-based therapeutics to augment regulatory T cells: a novel approach to treat myocarditis

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  • Post published:June 29, 2025
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Research Objective Use human cell therapy insights, specifically CDC-secreted EV analysis, to develop a noncoding RNA chemical entity for myocarditis treatment. Impact Key knowledge gap is how to recruit adaptive…

Continue ReadingRNA-based therapeutics to augment regulatory T cells: a novel approach to treat myocarditis

Novel Lipid Nanoparticles for Enhancing eNOS Synthesis for Cardioprotection Post Myocardial Infarction

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  • Post published:June 29, 2025
  • Post category:

Research Objective Our therapeutic candidate is a lipid nanoparticle that delivers a therapeutic dose of mRNA to the human heart, which transiently transfects of cells within the heart to improve…

Continue ReadingNovel Lipid Nanoparticles for Enhancing eNOS Synthesis for Cardioprotection Post Myocardial Infarction
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