Unraveling the developmental path from altered hematopoietic stem cells to leukemia in Down syndrome
Grant Award Details
Grant Type:
Grant Number:
DISC0-17610
Investigator(s):
Award Value:
$2,337,847
Status:
Pre-Active
Grant Application Details
Application Title:
Unraveling the developmental path from altered hematopoietic stem cells to leukemia in Down syndrome
Public Abstract:
Research Objective
Our goal is to map altered Trisomy 21 developmental hematopoiesis to understand the first steps of leukemia initiation in Myeloid Leukemia of Down syndrome
Impact
We will provide critical knowledge of how Trisomy 21 hematopoietic stem cell development is altered and the factors that predispose to leukemic transformation before birth
Our goal is to map altered Trisomy 21 developmental hematopoiesis to understand the first steps of leukemia initiation in Myeloid Leukemia of Down syndrome
Impact
We will provide critical knowledge of how Trisomy 21 hematopoietic stem cell development is altered and the factors that predispose to leukemic transformation before birth
