Disease Focus: Developmental Disorders
Defining the source of dysfunction in monogenic Intellectual Disability Syndrome neurons
Research Objective This study will use pluripotent stem cells derived from patients to determine why Intellectual Disabilities caused by mutations in chromatin regulatory proteins leads to neuronal defects. Impact Our study of intellectual disability syndromes will determine links between mutations and neuronal dysfunction Major Proposed Activities Our study of intellectual disability syndromes will determine links […]
Functional genomics to study cellular convergence across ASD risk genes in neurodevelopment
Research Objective Our objective is to enable scalable genetic screening to study how neurogenesis is impacted by risk genes implicated in human psychiatric disorders. Impact We will develop and apply state-of-the-art genomic analysis to seek mechanisms and disease modifying solutions. Major Proposed Activities Identifying and validating efficient gRNA for gene editing Identify risk gene effects […]
2016 Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration
Stem Cells Craniofacial Development and Disease
MicroRNAs in Human Stem Cell Differentiation and Mental Disorders
Many mental disorders are closely associated with problems that occur during brain development in early life. For instance, by 2 years of age, autistic children have larger brains than normal kids, likely due to, at least in part, excess production of neurons and support cells, the building blocks of the nervous system. In autistic brains, […]
Preeclampsia and Stem Cell Research: Mana Parast, UC-San Diego
Preeclampsia is a disorder of the placenta that complicates 5-8% of all pregnancies worldwide and is the leading cause of maternal death in the developed world. It’s also the leading cause of fetal growth restriction and there’s no cure except to deliver the baby. Due to this fact preeclampsia is the number one cause of […]
Preeclampsia and Stem Cell Research: The Parent’s Perspective
Preeclampsia is a disorder of the placenta that complicates 5-8% of all pregnancies worldwide and is the leading cause of maternal death in the developed world. It’s also the leading cause of fetal growth restriction and there’s no cure except to deliver the baby. Due to this fact preeclampsia is the number one cause of […]