Research Objective

A cell therapy product comprised of inhibitory neurons that can migrate, integrate and restore neurologic function after traumatic brain injury.

Impact

Traumatic brain injury

Major Proposed Activities

• Examine the most effective dose and safety profile of human iPSC-derived MGE cells grafted into rodent hippocampus.
• Determine whether human iPSC-derived MGE cells mature into appropriate cortical interneurons in the traumatically injured brain
• Evaluate the effect of human GABA neurons on synaptic activity in the injured brain
• Evaluate the therapeutic potential of human-derived interneurons

Nearly 6 million Americans – including 700,000 Californians – live with permanent physical or mental health problems resulting from a traumatic brain injury, but there are no treatments. We propose studies to create a cell therapy product that is capable of restoring neurologic function to these patients.