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Common molecular mechanisms in neurodegenerative diseases using patient based iPSC neurons

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  • Post published:May 24, 2025
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A major medical problem in CA is the growing population of individuals with neurodegenerative diseases, including Parkinson’s (PD) and Huntington’s (HD) disease. These diseases affect millions of people, sometimes during…

Continue ReadingCommon molecular mechanisms in neurodegenerative diseases using patient based iPSC neurons

Role of mechanical signaling in stem cell self-renewal and differentiation

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  • Post published:May 24, 2025
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Cells feel subtle but constant pushes and tugs from their neighbors inside living organisms. Surprisingly, these tiny mechanical cues have a profound effect on how stem cells grow, divide, and…

Continue ReadingRole of mechanical signaling in stem cell self-renewal and differentiation

Energy metabolism and aging pathways in human stem cell reprogramming and differentiation

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  • Post published:May 24, 2025
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The discovery that human skin cells can be reprogrammed into stem cells holds great promise for therapies for degenerative diseases. As many patients in need of regenerative medicine therapies are…

Continue ReadingEnergy metabolism and aging pathways in human stem cell reprogramming and differentiation

Genetic dissection of human cellular reprogramming to pluripotency

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  • Post published:May 24, 2025
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It is now possible to turn adult differentiated cells from a patient into human induced Pluripotent Stem (iPS) cells. These iPS cells hold enormous promise for new therapies in Regenerative…

Continue ReadingGenetic dissection of human cellular reprogramming to pluripotency

A new paradigm of lineage-specific reprogramming

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  • Post published:May 24, 2025
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Recently, we devised and reported a new regenerative medicine paradigm that entails temporal/transient overexpression of induced pluripotent stem cell based reprogramming factors in skin cells, leading to the rapid generation…

Continue ReadingA new paradigm of lineage-specific reprogramming

Prostaglandin pathway regulation of self-renwal in hematopoietic and leukemia stem cells

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  • Post published:May 24, 2025
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Leukemias are cancers of the blood cells that result from corruption of the normal controls that regulate blood-forming stem cells. They are serious causes of illness and death, and are…

Continue ReadingProstaglandin pathway regulation of self-renwal in hematopoietic and leukemia stem cells

Stem Cell Mechanisms Governing Discrete Waves of Gliogenesis in the Childhood Brain

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  • Post published:May 24, 2025
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White matter is the infrastructure of the brain, providing conduits for communication between neural regions. White matter continues to mature from birth until early adulthood, particularly in regions of brain…

Continue ReadingStem Cell Mechanisms Governing Discrete Waves of Gliogenesis in the Childhood Brain

Stem cell models to analyze the role of mutated C9ORF72 in neurodegeneration

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  • Post published:May 24, 2025
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Amyotrophic lateral sclerosis (ALS) is an idiopathic adult-onset degenerative disease characterized by progressive weakness from loss of upper and lower motor neurons. Onset is insidious, progression is essentially linear, and…

Continue ReadingStem cell models to analyze the role of mutated C9ORF72 in neurodegeneration

The HD iPSC Consortium: Repeat Length Dependent Phenotypes for Assay Development

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  • Post published:May 24, 2025
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Continue ReadingThe HD iPSC Consortium: Repeat Length Dependent Phenotypes for Assay Development

Use of human iPS cells to study spinal muscular atrophy

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  • Post published:May 24, 2025
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Spinal muscular atrophy (SMA) is one of the most common autosomal recessive disorders that cause infant mortality. SMA is caused by loss of the Survival of Motor Neuron (SMN) protein,…

Continue ReadingUse of human iPS cells to study spinal muscular atrophy
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