Building Cardiac Tissue from Stem Cells and Natural Matrices
Congestive heart failure afflicts 4.8 million people, with 400,000 new cases each year. Myocardial infarction (MI), also known as a "heart attack", leads to a loss of cardiac tissue and…
Mechanisms in Choroid Plexus Epithelial Development
Buried deep inside the brain are cells known as choroid plexus epithelial (CPe) cells. Although not as famous as other cells in the nervous system, CPe cells perform a large…
The roles of non-coding RNAs in the self-renewal and differentiation of pluripotent stem cells
There are thousands of cell types in the animal body, many of which can be derived from embryonic stem cells (ES cells), a pluripotent cell type that thrive in cell…
Mechanisms of small RNA regulation in early embryonic development
The promise of embryonic stem cells in regenerative medicine is based on their potential to make every cell in the body, a property coined pluripotency. With rapid recent advances in…
Stem Cells for Immune System Regeneration to Fight Cancer
This proposal will define the biology of stem cell engineering to produce a cancer-fighting immune system. The immune system protects our body against most outside threats. However, it frequently fails…
The molecular basis underlying adult neurogenesis during regeneration and tissue renewal
Regeneration of lost body parts has long fascinated humans, yet regeneration remains one of the great mysteries in biology. Forty years ago, studies on the mammalian brain provided evidence that…
Mechanisms Underlying the Diverse Functions of STAT3 in Embryonic Stem Cell Fate Regulation
Embryonic stem cells (ESCs) are derived from very early stage embryos. ESCs can be maintained in culture indefinitely while retain the ability to make any type of cell in the…
Regulation of Adult Stem Cell Proliferation by RAS and Cell-Permeable Proteins
Our research focuses on developing new tools and models for the next generation of doctors and scientists in all specialties of regenerative medicine. The major obstacles in regenerative medicine are…
Molecular dissection of adult liver regeneration to guide the generation of hepatocytes from pluripotent stem cells
The liver is a promising target for cell therapy since it supports and functionally integrates transplanted cells. Human liver contains more than 50 billion cells and more than 10% replacement…
Mechanism of Tissue Engineered Small Intestine Formation
Short Bowel Syndrome is an expensive, morbid condition with an increasing incidence. Fundamental congenital and perinatal conditions such as gastroschisis, malrotation, atresia, and necrotizing enterocolitis (NEC) may lead to short…
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