Force, Dimensionality and Stem Cell Fate
Human embryonic stem cells (hESCs) are cells derived from human embryos early in development before their fate has been sealed. These cells grow and differentiate in response to a variety…
Role of Chromatin Modifiers in Regulating Human Embryonic Stem Cell Pluripotency
The life of every human starts with a fertilized egg. This single cell starts to divide and, in a truly amazing process, gives rise to a developed human being. Although…
Reprogramming Differentiated Human Cells to a Pluripotent State
If the therapeutic potential of human embryonic stem (ES) cells is to be realized, the ability to produce pluripotent stem cells with defined genetic backgrounds is essential. Pluripotent cells, through…
Analysis of Candidate Neural Crest Cells Derived from Human ES Cells
Little is known about human Neurla Crest (NC) cells, a transient population of cells briefly present during very early human development; the reason why these cells are extremely difficult to…
Screening for Oncogenic Epigenetic Alterations in Human ES Cells
Embryonic stem cell-based therapies hold great promise for the treatment of many human diseases. These therapeutic strategies involve the culture and manipulation of embryonic stem cells grown outside the human…
EC regeneration in cerebrovascular ischemia: role of NO
Stroke is the third leading cause of death and the leading cause of disability in this country, affecting about 650,000 people in the US each year. Currently approved therapies for…
Profiling surface glycans and glycoprotein expression of human embryonic stem cells
Human embryonic stem cells can be changed into virtually any cell type in the adult body. Because of this unique capability, these cells have the potential to cure a vast…
Non-coding RNA as tool for the active control of stem cell differentiation
Stem cells are multipotent, meaning that they can develop into any cell type of the human body. Biomedical applications propose that, after introduction into humans, stem cells could replenish damaged…
Transcriptional Regulation of Human Embryonic Stem Cells
Embryonic Stem (ES) cells can be grown indefinitely in the lab and can be turned into any cell type of the human body. Because of these properties, it may one…
Sources of Genetic Instability in Human Embryonic Stem Cells.
The constant exposure of cells to endogenous and exogenous agents that inflict DNA damage requires active repair processes to eliminate potentially mutagenic events in stem cells leading to cancer. The…
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