Molecular mechanisms involved in adult neural stem cell maintenance
The adult brain contains a pool of stem cells, termed adult neural stem cells, that could be used for regenerative purposes in diseases that affect the nervous system. The goal…
A Novel Engineered Niche to Explore the Vasculogenic Potential of Embryonic Stem Cells
Cardiovascular diseases account for an estimated $330 billion in health care costs each year, afflict 61.8 million Americans, and will account for more than 1.5 million deaths in the U.S.…
Trithorax and Polycomb methyltransferase complexes in cell fate determination.
The physiological template of our genome, called chromatin, is composed of DNA wrapped around histone proteins. In the process of development the genome is interpreted in a way that is…
Genetic dissection of mesodermal commitment to the hematopoietic fates.
Genetic dissection of mesodermal commitment to hematopoietic fates. Hematopoietic cell transplantation is the gold standard for cell-based therapy and is routinely used to treat a wide variety of blood disorders…
Oral and Craniofacial Reconstruction Using Mesenchymal Stem Cells
The overall goal of this proposal is to explore a new stem cell-based treatment for major defects in the orofacial regions resulted from burns, physical injuries, genetic diseases, cancers, infectious…
Reprogramming of human somatic cells back to pluripotent embryonic stem cells
The ability to dedifferentiate or reverse lineage-committed cells to pluripotent/multipotent cells might overcome many of the obstacles (e.g. cell sources, immunocompatibility and bioethical concerns) associated with using other ES and…
Reprogramming of human somatic cells back to pluripotent embryonic stem cells
The ability to dedifferentiate or reverse lineage-committed cells to pluripotent/multipotent cells might overcome many of the obstacles (e.g. cell sources, immunocompatibility and bioethical concerns) associated with using other ES and…
Noncoding RNAs in Cell Fate Determination
The human body is composed of thousands of cell types, which all came originally from embryonic stem cells. Although all these cell types have the same genetic blueprint, different genes…
Human Immune System Mouse models as preclinical platforms for stem cell derived grafts
A major obstacle to stem cell based therapies is the immune response of the patient to stem cell derived tissue, which can be recognized as foreign and attacked by the…
Engineered immune tolerance by Stem Cell-derived thymic regeneration
Stem cell therapies have the potential to transform medicine by allowing the regeneration of tissues or organs damaged by disease or trauma. In order for stem cell therapies to proceed,…
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