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Reprogramming of human somatic cells back to pluripotent embryonic stem cells

  • Post author:
  • Post published:May 8, 2025
  • Post category:

The ability to dedifferentiate or reverse lineage-committed cells to pluripotent/multipotent cells might overcome many of the obstacles (e.g. cell sources, immunocompatibility and bioethical concerns) associated with using other ES and…

Continue ReadingReprogramming of human somatic cells back to pluripotent embryonic stem cells

Reprogramming of human somatic cells back to pluripotent embryonic stem cells

  • Post author:
  • Post published:May 8, 2025
  • Post category:

The ability to dedifferentiate or reverse lineage-committed cells to pluripotent/multipotent cells might overcome many of the obstacles (e.g. cell sources, immunocompatibility and bioethical concerns) associated with using other ES and…

Continue ReadingReprogramming of human somatic cells back to pluripotent embryonic stem cells

Noncoding RNAs in Cell Fate Determination

  • Post author:
  • Post published:May 8, 2025
  • Post category:

The human body is composed of thousands of cell types, which all came originally from embryonic stem cells. Although all these cell types have the same genetic blueprint, different genes…

Continue ReadingNoncoding RNAs in Cell Fate Determination

Human Immune System Mouse models as preclinical platforms for stem cell derived grafts

  • Post author:
  • Post published:May 8, 2025
  • Post category:

A major obstacle to stem cell based therapies is the immune response of the patient to stem cell derived tissue, which can be recognized as foreign and attacked by the…

Continue ReadingHuman Immune System Mouse models as preclinical platforms for stem cell derived grafts

Engineered immune tolerance by Stem Cell-derived thymic regeneration

  • Post author:
  • Post published:May 8, 2025
  • Post category:

Stem cell therapies have the potential to transform medicine by allowing the regeneration of tissues or organs damaged by disease or trauma. In order for stem cell therapies to proceed,…

Continue ReadingEngineered immune tolerance by Stem Cell-derived thymic regeneration

Inactivating NK cell reactivity to facilitate transplantation of stem cell derived tissue

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  • Post published:May 8, 2025
  • Post category:

One of the great promises of stem cell research is that it will one day be possible to prepare replacement cells or organs from stem cells such as embryonic stem…

Continue ReadingInactivating NK cell reactivity to facilitate transplantation of stem cell derived tissue

Regulatory T cell induced tolerance to ESC transplantation

  • Post author:
  • Post published:May 8, 2025
  • Post category:

The goals of this proposal are to utilize cell populations known to control immune reactions termed regulatory T cells and study their ability to protect embryonic stem cells (ESC) from…

Continue ReadingRegulatory T cell induced tolerance to ESC transplantation

Role of HLA in neural stem cell rejection using humanized mice

  • Post author:
  • Post published:May 8, 2025
  • Post category:

One of the key issues in stem cell transplant biology is solving the problem of transplant rejection. Despite over three decades of research in human embryonic stem cells, little is…

Continue ReadingRole of HLA in neural stem cell rejection using humanized mice

Role of HLA in neural stem cell rejection using humanized mice

  • Post author:
  • Post published:May 8, 2025
  • Post category:

One of the key issues in stem cell transplant biology is solving the problem of transplant rejection. Despite over three decades of research in human embryonic stem cells, little is…

Continue ReadingRole of HLA in neural stem cell rejection using humanized mice

Engineering Embryonic Stem Cell Allografts for Operational Tolerance

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  • Post published:May 8, 2025
  • Post category:

Stem cells, like all transplants not derived from an identical twin, are subject to scrutiny by the immune system and, without medical interventions that suppress the immune system, are usually…

Continue ReadingEngineering Embryonic Stem Cell Allografts for Operational Tolerance
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