Hiromitsu Nakauchi
Institution Name:
Stanford University
Total Awards:
3
Award Value:
$7,606,874
Awards as PI
| Program Type | Institution | Grant Title | Award Value |
|---|---|---|---|
| Research Leadership | Stanford University | Generation of functional cells and organs from iPSCs | $5,427,512 |
| Quest - Discovery Stage Research Projects | Stanford University | Novel Rejuvenated T Cell Immunotherapy for Lung Cancer | $1,968,456 |
| Inception - Discovery Stage Research Projects | Stanford University | Optimizing self-renewal signaling kinetics to stabilize ex vivo hematopoietic stem cell expansion | $210,906 |
Total: $7,606,874.00 |
Publications
- Stem Cell Reports 2015 A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy. (PubMed: 26321144)
- Development 2015 Interspecific in vitro assay for the chimera-forming ability of human pluripotent stem cells. (PubMed: 26023098)
- Nature 2016 Stem cells and interspecies chimaeras. (PubMed: 27905428)
- Nature 2017 Interspecies organogenesis generates autologous functional islets. (PubMed: 28117444)
- Cell Stem Cell 2016 Inhibition of Apoptosis Overcomes Stage-Related Compatibility Barriers to Chimera Formation in Mouse Embryos. (PubMed: 27814480)
- Cell Syst 2017 Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity. (PubMed: 29073372)
- Stem Cell Reports 2017 An All-Recombinant Protein-Based Culture System Specifically Identifies Hematopoietic Stem Cell Maintenance Factors. (PubMed: 28238792)
- Dev Cell 2016 Spatiotemporal Reconstruction of the Human Blastocyst by Single-Cell Gene-Expression Analysis Informs Induction of Naive Pluripotency. (PubMed: 27404362)
- Cell Stem Cell 2018 iPSC-Derived Organs In Vivo: Challenges and Promise. (PubMed: 29304339)
- Annu Rev Cell Dev Biol 2017 Lessons from Interspecies Mammalian Chimeras. (PubMed: 28806099)
- Cell Stem Cell 2018 Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment. (PubMed: 29625072)
- Sci Rep 2017 CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep. (PubMed: 29234093)
- Stem Cell Reports 2017 In Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma. (PubMed: 28943250)
- Stem Cell Reports 2018 Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications. (PubMed: 29478892)
- Cell Stem Cell 2018 Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress. (PubMed: 29706577)
- Curr Opin Genet Dev 2018 Interspecies chimeras. (PubMed: 29859382)
- ACS Synth Biol 2018 Designing Motif-Engineered Receptors To Elucidate Signaling Molecules Important for Proliferation of Hematopoietic Stem Cells. (PubMed: 29920201)
- J Hepatol 2018 Chimeric liver transplantation reveals interspecific graft remodelling. (PubMed: 30031887)
- Biomaterials 2018 Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold. (PubMed: 30149262)
- Stem Cell Reports 2018 Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation. (PubMed: 30245211)
- Transgenic Res 2018 Mosaicism diminishes the value of pre-implantation embryo biopsies for detecting CRISPR/Cas9 induced mutations in sheep. (PubMed: 30284144)
- Sci Rep 2018 An interspecies barrier to tetraploid complementation and chimera formation. (PubMed: 30327488)
- Sci Rep 2018 Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate. (PubMed: 30367142)
- Cell Rep 2018 Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia. (PubMed: 30380403)
- iScience 2018 Intra-embryo Gene Cassette Knockin by CRISPR/Cas9-Mediated Genome Editing with Adeno-Associated Viral Vector. (PubMed: 30447647)
- Science 2018 Changing concepts in hematopoietic stem cells. (PubMed: 30467158)
- Nat Methods 2018 Efficient scarless genome editing in human pluripotent stem cells. (PubMed: 30504872)
- Exp Hematol 2018 Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity. (PubMed: 29705267)
- Science 2016 Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation. (PubMed: 27934766)
- Methods Mol Biol 2019 Generation of Antigen-Specific T Cells from Human Induced Pluripotent Stem Cells. (PubMed: 30649763)
- Nat Commun 2019 Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats. (PubMed: 30723213)
- Sci Rep 2019 LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. (PubMed: 30765795)
- Cell Stem Cell 2019 Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination. (PubMed: 31051134)
- Nature 2019 Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. (PubMed: 31142833)