Alysson Muotri
Institution Name:
University of California, San Diego
Total Awards:
6
Award Value:
$11,561,924
Awards as PI
Publications
- Exp Neurol 2012 Stem cells and modeling of autism spectrum disorders. (PubMed: 23036599)
- Biol Psychiatry 2013 Novel Tools, Classic Techniques: Evolutionary Studies Using Primate Pluripotent Stem Cells. (PubMed: 24041506)
- Stem Cell Res 2013 Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells. (PubMed: 23759711)
- Nat Neurosci 2014 Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. (PubMed: 25108912)
- Sci Rep 2015 Systematic optimization of human pluripotent stem cells media using Design of Experiments. (PubMed: 25940691)
- Neurotherapeutics 2015 The Use of Induced Pluripotent Stem Cell Technology to Advance Autism Research and Treatment. (PubMed: 25851569)
- Biol Psychiatry 2015 The Human Model: Changing Focus on Autism Research. (PubMed: 25861701)
- Hum Mol Genet 2016 Cockayne Syndrome-derived neurons display reduced synapse density and altered neural network synchrony. (PubMed: 26755826)
- Proc Natl Acad Sci U S A 2016 KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome. (PubMed: 26733678)
- Proc Natl Acad Sci U S A 2016 Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction. (PubMed: 26944080)
- Brain Res 2016 Modeling autism spectrum disorders with human neurons. (PubMed: 26854137)
- Nature 2016 A human neurodevelopmental model for Williams syndrome. (PubMed: 27509850)
- J Cell Sci 2016 Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation. (PubMed: 27528403)
- Hum Mol Genet 2016 IGF1 neuronal response in the absence of MECP2 is dependent on TRalpha 3. (PubMed: 28007906)
- Neurogenesis (Austin) 2017 Modeling Williams syndrome with induced pluripotent stem cells. (PubMed: 28229087)
- Adv Exp Med Biol 2017 TRPC Channels and Mental Disorders. (PubMed: 28508319)
- Cell Stem Cell 2017 Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation. (PubMed: 28803918)
- Biochem Biophys Res Commun 2017 The L1 adhesion molecule normalizes neuritogenesis in Rett syndrome-derived neural precursor cells. (PubMed: 29050935)
- Hum Mol Genet 2017 Modeling neuro-immune interactions during Zika virus infection. (PubMed: 29048558)
- Sci Rep 2018 Blocking Zika virus vertical transmission. (PubMed: 29352135)
- Sci Rep 2017 Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis. (PubMed: 29150641)
- Sci Transl Med 2018 Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs. (PubMed: 29743351)
- Mol Cell Probes 2018 The contribution of GTF2I haploinsufficiency to Williams syndrome. (PubMed: 29305905)
- Biol Psychiatry 2018 Modeling the Interplay Between Neurons and Astrocytes in Autism Using Human Induced Pluripotent Stem Cells. (PubMed: 29129319)
- Cell Rep 2019 Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease. (PubMed: 30699348)
- Elife 2019 Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. (PubMed: 30730291)
- Trends Mol Med 2018 Brain Organoids and the Study of Neurodevelopment. (PubMed: 30377071)
- PLoS One 2019 Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function. (PubMed: 30789962)
- Semin Cell Dev Biol 2019 Brain organoids as a model system for human neurodevelopment and disease. (PubMed: 30904636)
- Physiology (Bethesda) 2019 Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders. (PubMed: 31389776)
- Cell Stem Cell 2019 Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development. (PubMed: 31474560)
- Front Neurol 2019 Transposable Elements, Inflammation, and Neurological Disease. (PubMed: 31481926)
- Cell Res 2020 Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions. (PubMed: 32499560)
- EMBO Mol Med 2021 Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids. (PubMed: 33501759)
- Semin Cell Dev Biol 2022 Brain organoids, consciousness, ethics and moral status. (PubMed: 35339359)
- Mol Psychiatry 2022 Advancing preclinical models of psychiatric disorders with human brain organoid cultures. (PubMed: 35948659)
- Front Bioeng Biotechnol 2022 Recent advancements and future requirements in vascularization of cortical organoids. (PubMed: 36406234)
