Grant Award Details
- Programmatic Objectives met, which include conference attendance, Journal clubs, courses , and trainees successful research in the hosting labs.
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Grant Application Details
- Stem Cell Training Program
The Stem Cell Training Program includes: experienced, well-funded mentors; essential techniques, methodologies, and facilities relevant to basic, translational, and clinical training in stem cell research; established graduate and training programs that provide the spectrum of training experiences; a clinical enterprise that includes a medical school, teaching hospital, and exceptional infrastructure including a CIRM Shared Research Facility and CIRM Stem Cell Institute; core facilities that provide essential equipment and expertise in stem cell biology and related areas such as animal models, bioengineering, genomics, and imaging; and a clinical program to ensure the translation of bench research to new therapies for human diseases. The program also includes a strong, collaborative framework in which to mentor and cultivate students and young investigators using a team approach. The overarching objective is to provide chosen scholars an integrated experience with state-of-the-art multidisciplinary team training to ensure they become productive, critical thinking, highly trained, and well-rounded collaborative scientists with research careers in stem cell biology and regenerative medicine. This will be accomplished through integration of established campus opportunities and partnering with other related programs and institutions. Faculty from many schools and colleges provide a collaborative structure that has been successful in the current and other funded training programs. Success with the current stem cell training program justifies support for 16 trainees (6 predoctoral, 6 postdoctoral, 4 clinical fellows). Formal training will be provided through mentored research, a didactic curriculum, existing courses in graduate education, established courses that focus on the ethical, legal, and social implications of stem cell research, stem cell biology and regenerative medicine, and a weekly journal club, monthly seminar series with speakers from around the nation, an annual symposium, and an annual training program retreat. The curriculum is designed to bring all scholars and their mentoring teams together throughout the course of the training. The mentors are responsible for selecting and mentoring candidates, evaluating trainee progress, and assisting trainees with career development. The quality of the mentor is a major focus when the selection committee chooses trainees. The leadership of the program spans basic, translational, and clinical research. An Internal Advisory Committee includes the leadership team and representatives from various schools and colleges to oversee the formal process for scholar selection, and expectations for trainees and mentors. Program effectiveness is evaluated through an established educational evaluation program.
The CIRM Stem Cell Training Program will provide significant benefit to the State of California and its citizens in the following ways: • Train diverse scholars to be the next generation of regenerative biomedical science and medicine leaders, advancing basic and clinical translational science as well as mentoring another generation of scholars. • Provide unique shared resources that are used by all stem cell/regenerative medicine scientists and clinicians in California. • Develop team-oriented investigators who will facilitate intra-institutional and inter-institutional research as well as reaching out to industry partners to facilitate and implement new therapies for a host of human diseases. • Educate our community partners about stem cell research including the science as well as the ethical, legal, and social implications of regenerative medicine and stem cell research.
Publications
- J Vis Exp (2015) Calibrated forceps model of spinal cord compression injury. (PubMed: 25938880)
- Neural Dev (2015) Dynamic regulation of mRNA decay during neural development. (PubMed: 25896902)
- Stem Cell Res Ther (2015) Multiple intravenous injections of allogeneic equine mesenchymal stem cells do not induce a systemic inflammatory response but do alter lymphocyte subsets in healthy horses. (PubMed: 25888916)
- Fetal Diagn Ther (2015) Age Does Matter: A Pilot Comparison of Placenta-Derived Stromal Cells for in utero Repair of Myelomeningocele Using a Lamb Model. (PubMed: 26159889)
- Proteomics Clin Appl (2015) Cardiac extracellular matrix proteomics: Challenges, techniques, and clinical implications. (PubMed: 26200932)
- J Transl Med (2015) Embolization of the first diagonal branch of the left anterior descending coronary artery as a porcine model of chronic trans-mural myocardial infarction. (PubMed: 26047812)
- World Neurosurg (2015) Efficient Generation of Induced Pluripotent Stem and Neural Progenitor Cells From Acutely Harvested Dura Mater Obtained During Ventriculoperitoneal Shunt Surgery. (PubMed: 26074438)
- Stem Cells Transl Med (2015) Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele. (PubMed: 25911465)
- J Pediatr Surg (2015) Development of a locomotor rating scale for testing motor function in sheep. (PubMed: 25840074)
- Nat Commun (2014) Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells. (PubMed: 25034944)
- Stem Cells Dev (2014) Gastrointestinal microbes interact with canine adipose-derived mesenchymal stem cells in vitro and enhance immunomodulatory functions. (PubMed: 24803072)
- Acta Biomater (2014) Enhanced trophic factor secretion by mesenchymal stem/stromal cells with Glycine-Histidine-Lysine (GHK)-modified alginate hydrogels. (PubMed: 24468583)
- Tissue Eng Part A (2014) Lysophosphatidic acid protects human mesenchymal stromal cells from differentiation-dependent vulnerability to apoptosis. (PubMed: 24131310)
- Development (2014) Histone H3.3 regulates dynamic chromatin states during spermatogenesis. (PubMed: 25142466)
- Nat Commun (2013) hESC-derived Olig2(+) progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury. (PubMed: 23880652)
- Stem Cells (2013) Generation and characterization of spiking and non-spiking oligodendroglial progenitor cells from embryonic stem cells. (PubMed: 23940003)
- Dev Biol (2013) Germ cells are required to maintain a stable sexual phenotype in adult zebrafish. (PubMed: 23348677)
- PLoS One (2013) Lysophosphatidic acid enhances stromal cell-directed angiogenesis. (PubMed: 24312635)
- Circ Arrhythm Electrophysiol (2013) Mechanism-Based Facilitated Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes. (PubMed: 23392582)
- Exp Hematol (2013) The Migration of Hematopoietic Progenitors from the Fetal Liver to the Fetal Bone Marrow: Lessons Learned and Possible Clinical Applications. (PubMed: 23395775)
- Biomaterials (2013) Factors affecting the structure and maturation of human tissue engineered skeletal muscle. (PubMed: 23643182)
- PLoS One (2012) Single-Cell Analysis of Murine Long-Term Hematopoietic Stem Cells Reveals Distinct Patterns of Gene Expression during Fetal Migration. (PubMed: 22276210)
- J Neurosci (2012) Disruption of NMDA Receptors in Oligodendroglial Lineage Cells Does Not Alter Their Susceptibility to Experimental Autoimmune Encephalomyelitis or Their Normal Development. (PubMed: 22238099)
- Mol Cancer Res (2012) Human ESC Self-Renewal Promoting miRNAs Induce Epithelial-Mesenchymal Transition in Hepatocytes by Controlling the PTEN and TGFbeta Tumor Suppressor Signaling Pathways. (PubMed: 22622027)
- J Biomed Mater Res B Appl Biomater (2012) Cardiac tissue development for delivery of embryonic stem cell-derived endothelial and cardiac cells in natural matrices. (PubMed: 22888031)