Grant Award Details

Pro-healing biomaterial for treating lung inflammation associated with COVID-19
Grant Number: 
DISC2COVID19-12007
Project Objective: 
  • The objective of this award is to develop a soluble decellularized extracellular matrix that can dampen acute lung inflammation and improve pulmonary function in COVID-19 patients.
Investigator: 
Disease Focus: 
COVID-19
Infectious Disease
Respiratory Disorders
Human Stem Cell Use: 
Adult Stem Cell
Award Value: 
$221,758
Status: 
Active

Grant Application Details

Application Title: 
  • Pro-healing biomaterial for treating lung inflammation associated with COVID-19
Public Abstract: 

Research Objective

Pro-healing biomaterial to treat lung inflammation and promote recovery.

Impact

COVID-19 associated acute respiratory distress syndrome

Major Proposed Activities

  • Evaluate biomaterial for ability to reduce lung inflammation in rodent model
  • Evaluate biomaterial for ability to recruit stem cells in the lung
  • Evaluate biomaterial for ability to improve lung function in rodent model
  • Evaluate biomaterial for ability to recruit human stem cells
Statement of Benefit to California: 

In late-June 2020, there are more than 5,700 Californians who are currently hospitalized because of COVID-19 (tested positive or suspected) with over 1,300 confirmed COVID-19 patients in the ICU. A significant number of severe cases involve a negative inflammatory response in the lungs leading to respiratory failure. We aim to develop a new therapeutic that can treat this inflammation and promote lung healing thereby having potential benefit to thousands of Californians.