Grant Award Details

Mesenchymal stem cell extracellular vesicles as therapy for pulmonary fibrosis
Grant Number: 
DISC2-11192
Investigator: 
Type: 
PI
Disease Focus: 
Lung Disease, Fibrosis
Respiratory Disorders
Human Stem Cell Use: 
Adult Stem Cell
Award Value: 
$865,282
Status: 
Pre-Active

Grant Application Details

Application Title: 
  • Mesenchymal stem cell extracellular vesicles as therapy for pulmonary fibrosis
Public Abstract: 

Research Objective

We propose to develop mesenchymal stem cell derived extracellular vesicles (MSC-EV) as treatment for lung fibrosis

Impact

MSC-EV are promising for several lung diseases, but we need to better understand how they work, where they go in the body, and whether there is a subset of MSC-EV with better efficacy

Major Proposed Activities

  • To define the molecular characteristics, content, and effects of subsets of MSC-EV that do or don't express the Thy-1
    protein
  • To define the distribution of Thy-1 positive and negative MSC-EV in the body in the setting of lung fibrosis, and define
    what cells they interact with
  • To compare the effectiveness of Thy-1(+) and Thy-1(-) MSC-EV in treating lung fibrosis of different causes, in comparison
    to existing treatments
Statement of Benefit to California: 

There are estimated to be over 7000 individuals in California with idiopathic pulmonary fibrosis (IPF), an incurable and
fatal disease. Current treatments only slow the disease progression, but do not cure IPF. Many of these individuals
undergo lung transplantation which is very costly and at best adds a few years to life expectancy. Knowledge from this
project may benefit other types of fibrosis such as liver fibrosis and heart failure.