Drivers of trophoblast stem/progenitor cell identity in human placenta
Grant Award Details
Grant Type:
Grant Number:
DISC0-13757
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$993,881
Status:
Active
Grant Application Details
Application Title:
Drivers of trophoblast stem/progenitor cell identity in human placenta
Public Abstract:
Research Objective
This proposal will elucidate the mechanisms that identify a stem/progenitor cell population in the human placenta.
Impact
This proposal addresses our current knowledge gap on human placental development related to formation of the maternal/fetal interface during pregnancy, and placenta-associated pregnancy complications.
Major Proposed Activities
This proposal will elucidate the mechanisms that identify a stem/progenitor cell population in the human placenta.
Impact
This proposal addresses our current knowledge gap on human placental development related to formation of the maternal/fetal interface during pregnancy, and placenta-associated pregnancy complications.
Major Proposed Activities
- Identification of DNA regions, called enhancers, regulating placenta stem/progenitor cell-specific identity
- Identification of novel proteins regulating placental stem/progenitor cell-specific identity
- Construction of a reference for human placenta stem/progenitor cells in uncomplicated pregnancies
- Identification of abnormal mechanisms in placental stem/progenitor cells affected by Trisomy 21
Statement of Benefit to California:
California has a significant racial/ethnic diversity, with 14.5% Asian and 5.8% Black or African American. Racial/ethnic minority groups are at higher risk of pregnancy complications due to placental defects. This proposal will result in the development of strategies for prevention, detection, and intervention for various placental disorders, decrease pregnancy loss, and improve pregnancy outcomes, with impact on the physical/mental well-being as well as economy across Californian citizens.
Publications
- J Mol Endocrinol (2024): Conserved and divergent features of trophoblast stem cells. (PubMed: 38276878)
