Name:
Institution:
Type:
PI
Grant Award Details
Developing a personalized approach to beta cell replacement for patients with a genetic form of diabetes
Grant Type:
Grant Number:
DISC1-08868
Project Objective:
To determine the functional requirement for NEUROGENIN3 in the differentiation, maintenance, function, and survival of human pancreatic endocrine cells.
Investigator:
Disease Focus:
Diabetes
Metabolic Disorders
Human Stem Cell Use:
iPS Cell
Cell Line Generation:
iPS Cell
Award Value:
$179,995
Status:
Closed
Progress Reports
Reporting Period:
Year 2
View Report
Grant Application Details
Application Title:
- Developing a personalized approach to beta cell replacement for patients with a genetic form of diabetes
Public Abstract:
Research Objective
To correct a gene mutation in a patient's stem cells and produce functional replacement cells for the patient to cure their diabetes.
Impact
WE expect that this project can serve as a model for developing new treatments for patients with certain forms of genetic diabetes.
Major Proposed Activities
- To understand how the patient's gene mutation affects the differentiation, function, and survival of stem cell derived insulin cells
- To correct the patient's mutation in stem cells, then generate new insulin cells and test if they are fully functional.
Statement of Benefit to California:
California is already a leader in advancing stem cell technology. If we are successful, we believe that California can become the center for patients with certain forms of diabetes to come to for treatment.
