Autologous therapy for Parkinson’s disease: single cell RNAseq for in depth characterization of transplanted cells
Grant Award Details
Grant Number:
DISC2P-11595
Investigator(s):
Disease Focus:
Human Stem Cell Use:
Award Value:
$177,579
Status:
Closed
Progress Reports
Reporting Period:
Year 1
Grant Application Details
Application Title:
Autologous therapy for Parkinson's disease: single cell RNAseq for in depth characterization of transplanted cells
Public Abstract:
Research Objective
We are developing a durable patient-specific dopamine neuron replacement therapy for Parkinson's disease
Impact
Parkinson's disease is diagnosed when half of the dopamine (DA) neurons are lost from the brain's substantia nigra. Autologous DA neurons are derived from patients and transplanted as a replacement.
Major Proposed Activities
["Perform single cell RNA sequencing of developing iPSC-derived A9 dopamine neurons from 3 patients at 3 time points.", "Use bioinformatic analysis to create a profile of cells at their optimum transplantations stage.", "Integrate the single cell analysis into NeuroTest."]
We are developing a durable patient-specific dopamine neuron replacement therapy for Parkinson's disease
Impact
Parkinson's disease is diagnosed when half of the dopamine (DA) neurons are lost from the brain's substantia nigra. Autologous DA neurons are derived from patients and transplanted as a replacement.
Major Proposed Activities
["Perform single cell RNA sequencing of developing iPSC-derived A9 dopamine neurons from 3 patients at 3 time points.", "Use bioinformatic analysis to create a profile of cells at their optimum transplantations stage.", "Integrate the single cell analysis into NeuroTest."]
Statement of Benefit to California:
Thousands of Californians suffer from the degenerative effects of Parkinson's disease, a disease for which there is no cure. There is hope, however, that stem cells could provide the key to providing long-term relief. Our study seeks to treat patients with cells derived from their own stem cells, a process which could be applied to other diseases such as diabetes and heart disease and could potentially be used to the benefit of many of the citizens of California.