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Molecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC

  • Post author:
  • Post published:May 21, 2025
  • Post category:

Heart disease is the number one cause of death and disability in California and in the United States. Especially devastating is Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), an inherited form of…

Continue ReadingMolecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC

Molecular determinants of accurate differentiation from human pluripotent stem cells

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  • Post published:May 21, 2025
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The use of human pluripotent stem cells for cell-based therapeutics is predicated on the ability to convert these cells into functional equivalents of those lost in disease or injury. However,…

Continue ReadingMolecular determinants of accurate differentiation from human pluripotent stem cells

Understanding the role of LRRK2 in iPSC cell models of Parkinson’s Disease

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  • Post published:May 21, 2025
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The goal of this research is to utilize novel research tools to investigate the molecular mechanisms that cause Parkinson’s disease (PD). The proposed work builds on previous funding from CIRM…

Continue ReadingUnderstanding the role of LRRK2 in iPSC cell models of Parkinson’s Disease

Identifying sources of mutation in human induced pluripotent stem cells by whole genome sequencing

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  • Post published:May 21, 2025
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Stem cell research offers new tools to help treat and cure diseases that affect diverse cells types in the body such as neurological diseases, heart disease and diabetes by producing…

Continue ReadingIdentifying sources of mutation in human induced pluripotent stem cells by whole genome sequencing

Induced Pluripotent Stem Cells for Tissue Regeneration

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  • Post published:May 21, 2025
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Induced pluripotent stem cells (iPSCs) have tremendous potential for patient-specific cell therapies, which bypasses immune rejection issues and ethical concerns for embryonic stem cells (ESCs). However, to fully harness the…

Continue ReadingInduced Pluripotent Stem Cells for Tissue Regeneration

Cellular tools to study brain diseases affecting synaptic transmission

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  • Post published:May 21, 2025
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There is a group of brain diseases that are caused by functional abnormalities. The brains of patients afflicted with these diseases which include autism spectrum disorders, schizophrenia, depression, and mania…

Continue ReadingCellular tools to study brain diseases affecting synaptic transmission

Antibody tools to deplete or isolate teratogenic, cardiac, and blood stem cells from hESCs

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  • Post published:May 21, 2025
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Purity is as important for cell-based therapies as it is for treatments based on small-molecule drugs or biologics. Pluripotent stem cells possess two properties: they are capable of self regeneration…

Continue ReadingAntibody tools to deplete or isolate teratogenic, cardiac, and blood stem cells from hESCs

Use of iPS cells (iPSCs) to develop novels tools for the treatment of spinal muscular atrophy.

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  • Post published:May 21, 2025
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Spinal Muscular Atrophy (SMA) is one of the most common lethal genetic diseases in children. One in thirty five people carry a mutation in a gene called survival of motor…

Continue ReadingUse of iPS cells (iPSCs) to develop novels tools for the treatment of spinal muscular atrophy.

Engineering Defined and Scaleable Systems for Dopaminergic Neuron Differentiation of hPSCs

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  • Post published:May 21, 2025
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Human pluripotent stem cells (hPSC) have the capacity to differentiate into every cell in the adult body, and they are thus a highly promising source of differentiated cells for the…

Continue ReadingEngineering Defined and Scaleable Systems for Dopaminergic Neuron Differentiation of hPSCs

Editing of Parkinson’s disease mutation in patient-derived iPSCs by zinc-finger nucleases

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  • Post published:May 21, 2025
  • Post category:

The goal of this proposal is to establish a novel research tool to explore the molecular basis of Parkinson’s disease (PD) - a critical step toward the development of new…

Continue ReadingEditing of Parkinson’s disease mutation in patient-derived iPSCs by zinc-finger nucleases
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