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Enhancing healing via Wnt-protein mediated activation of endogenous stem cells

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  • Post published:June 4, 2025
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All adult tissues contain stem cells. Some tissues, like bone marrow and skin, harbor more adult stem cells; other tissues, like muscle, have fewer. When a tissue or organ is…

Continue ReadingEnhancing healing via Wnt-protein mediated activation of endogenous stem cells

Development of a Stem Cell-based Transplantation Strategy for Treating Age-related Macular Degeneration

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  • Post published:June 4, 2025
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Age related macular degeneration (AMD) is a blinding disease of the elderly affecting nearly one in three individuals over the age of 75. Central vision is lost in AMD, severely…

Continue ReadingDevelopment of a Stem Cell-based Transplantation Strategy for Treating Age-related Macular Degeneration

Neural Stem Cells as a Developmental Candidate to Treat Alzheimer Disease

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  • Post published:June 4, 2025
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Alzheimer disease (AD), the most common cause of dementia among the elderly and the third leading cause of death, presently afflicts over 5 million people in the USA, including over…

Continue ReadingNeural Stem Cells as a Developmental Candidate to Treat Alzheimer Disease

Sustained siRNA production from human MSC to treat Huntingtons Disease and other neurodegenerative disorders

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  • Post published:June 4, 2025
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One in every ten thousand people in the USA have Huntington's Disease, and it impacts many more. Multiple generations within a family can inherit the disease, resulting in escalating health…

Continue ReadingSustained siRNA production from human MSC to treat Huntingtons Disease and other neurodegenerative disorders

Role of Innate Immunity in hematopoeitic stem cell-mediated allograft tolerance

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  • Post published:June 4, 2025
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The research proposed in this project has very high potential to identify new medications to boost the natural ability of stem cells to prevent rejection of transplanted organs. This is…

Continue ReadingRole of Innate Immunity in hematopoeitic stem cell-mediated allograft tolerance

Engineered immune tolerance by Stem Cell-derived thymic regeneration

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  • Post published:June 4, 2025
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Stem cell therapies have the potential to transform medicine by allowing the regeneration of tissues or organs damaged by disease or trauma. In order for stem cell therapies to proceed,…

Continue ReadingEngineered immune tolerance by Stem Cell-derived thymic regeneration

Inactivating NK cell reactivity to facilitate transplantation of stem cell derived tissue

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  • Post published:June 4, 2025
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One of the great promises of stem cell research is that it will one day be possible to prepare replacement cells or organs from stem cells such as embryonic stem…

Continue ReadingInactivating NK cell reactivity to facilitate transplantation of stem cell derived tissue

Engineering Embryonic Stem Cell Allografts for Operational Tolerance

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  • Post published:June 4, 2025
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Stem cells, like all transplants not derived from an identical twin, are subject to scrutiny by the immune system and, without medical interventions that suppress the immune system, are usually…

Continue ReadingEngineering Embryonic Stem Cell Allografts for Operational Tolerance

Application of Tolerogenic Dendritic Cells for Hematopoietic Stem Cell Transplantation

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  • Post published:June 4, 2025
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The immune system protects us from invading pathogens, but has to be kept in check to prevent harmful responses to our own tissues. Unique immune “suppressor” cells have been recently…

Continue ReadingApplication of Tolerogenic Dendritic Cells for Hematopoietic Stem Cell Transplantation

Generation of regulatory T cells by reprogramming

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  • Post published:June 4, 2025
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The goal of our research is to develop efficient methods for making a particular class of immune-system cells known as regulatory T cells (Tregs). Tregs have the potential to be…

Continue ReadingGeneration of regulatory T cells by reprogramming
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