Multiple Sclerosis therapy: Human Pluripotent Stem Cell-Derived Neural Progenitor Cells
Multiple Sclerosis (MS) is a disease of the central nervous system (CNS) caused by inflammation and loss of cells that produce myelin, which normally insulates and protects nerve cells. MS…
Targeting Stem Cells to Enhance Remyelination in the Treatment of Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune disease in which the myelin sheath that insulates neurons is destroyed, resulting in loss of proper neuronal function. Existing treatments for MS are based…
Human stem cell derived oligodendrocytes for treatment of stroke and MS
Strokes that affect the nerves cells, i.e., “gray matter”, consistently receive the most attention. However, the kind of strokes that affecting the “wiring” of the brain, i.e., “white matter”, cause…
Human Embryonic Stem Cells and Remyelination in a Viral Model of Demyelination
Multiple sclerosis (MS) is the most common neurologic disease affecting young adults under the age of 40 with the majority of MS patients diagnosed in the second or third decade…
Improving the efficacy and tolerability of clinically validated remyelination-inducing molecules using developable combinations of approved drugs
Research Objective The candidate is a fixed dose binary small molecule drug combination, consisting of two agents that act synergistically on a multipotent stem cell population in the CNS to…
Advancing Toward Multiple Sclerosis Therapies Using Stem Cells
Dr. Tom Lane of the University of Utah (formerly a CIRM grantee at UC-Irvine) describes his lab's experimental results that show a dramatic reversal in the debilitating effects of a…
Living with Multiple Sclerosis: Hope for Stem Cell Therapies | Nan Luke
For more information about CIRM-funded MS research, visit our fact sheet. In her twenties, the left side of Nan Luke's body went numb from the bottom of her foot up…
