Development of a clinical-grade extracorporeal liver support system using human induced pluripotent stem cell-derived hepatic cells

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Liver failure is the fourth leading cause of adult death in California. Because liver cells can regenerate, some patients with liver failure could be saved without having to undergo organ…

Continue ReadingDevelopment of a clinical-grade extracorporeal liver support system using human induced pluripotent stem cell-derived hepatic cells

Gene therapy-corrected autologous hepatocyte-like cells from induced pluripotent stem cells for the treatment of pediatric single enzyme disorders

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Liver transplantation (LT) has been used to treat a variety of liver diseases. Within hours after birth, neonates can present with disorders of the urea cycle (UCDs), the critical metabolic…

Continue ReadingGene therapy-corrected autologous hepatocyte-like cells from induced pluripotent stem cells for the treatment of pediatric single enzyme disorders