Endodermal differentiation of human ES cells
The goals of this proposal are to investigate endodermal differentiation and proliferation in human ES cell cultures. Endodermal cells give rise to the epithelial lining of the respiratory and digestive…
Differentiation of Human Embryonic Stem Cells to Intestinal Fates
The roughly 25 feet of intestine in the adult human play numerous essential roles in daily life, such as nutrient absorption, secretion of hormones, and serving as a barrier to…
Cell Therapy for Diabetes
Diabetes exacts a tremendous toll on patients, their families, and society in general. Autoimmune Type 1 diabetes, often called juvenile-onset diabetes, is caused by a person’s own immune system mistakenly…
Unlocking the regenerative potential of hepatocyte plasticity for diseases of the biliary system
Research Objective The research will generate the know-how for replacing lost or injured bile ducts in the liver by reprogramming an abundant and related cell type that normally has a…
Next generation stem cell transplantation approaches for pediatric neurodegenerative disorders
Research Objective A complete methodology for high efficiency, minimal toxicity hematopoietic stem cell transplantation for treatment of pediatric neurodegenerative disorders. Impact Improve treatment and outcomes for patients with neurodegenerative disorders…
Developing replacement islet cells for diabetes using human stem cells
Research Objective We will identify genetic regulators and intercellular signals that promote islet cell function, and apply our work to advance stem cell biology for generating replacement islets to reverse…
Immune cloaking of human stem cell-derived insulin-producing cells for curative cell therapy without immunosuppression
Research Objective The goal of our project is to generate cells for replacement therapy in patients that have reduced ability to trigger the immune response in the recipient and therefore…
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