Disease Focus: Metabolic Disorders

Skin-derived precursor cells for the treatment of enteric neuromuscular dysfunction

The intestine performs the essential function of absorbing food and water into the body. Without a functional intestine, children and adults cannot eat normal meals, and these patients depend on intravenous nutrition to sustain life. Many of these patients do not have a neural system that coordinates the function of the intestine. These patients have […]

Development of a clinical-grade extracorporeal liver support system using human induced pluripotent stem cell-derived hepatic cells

Liver failure is the fourth leading cause of adult death in California. Because liver cells can regenerate, some patients with liver failure could be saved without having to undergo organ transplantation if their liver function could be supported temporarily. Here, we propose to develop a device to support these patients called the “extracorporeal liver support […]

Innovation and Translational Stem Cell Therapy for Diabetes and Neurological Diseases: Paving the way for real life solutions

2011 Rachmiel Levine Diabetes and Obesity Symposium: Advances in Diabetes Research

2012 Rachmiel Levine Diabetes and Obesity Symposium: Advances in Diabetes Research

2013 Rachmiel Diabetes and Obesity Levine Symposium – Advances in Diabetes Research

2009 Rachmiel Levine Diabetes and Obesity Symposium: Advances in Diabetes Biology, Immunology and Cell Therapy

A CIRM Disease Team for the Treatment and Cure of Diabetes

This proposal is for the establishment of a group of faculty, staff and industrial partners to develop a proposal for a Diabetes Disease Team. Diabetes is one of the most devastating diseases. Inadequate blood glucose control results on many long term complications including: kidney disease, blindness, amputation and nerve damage. The diabetes epidemic affects almost […]

Engineered matrices for control of lineage commitment in human pancreatic stem cells

Patients with end-stage type 1 diabetes (T1D) can be effectively managed by allogeneic islet transplantation. However, a severe cadaveric organ shortage greatly limits use of this promising procedure. Stem cells have the potential to provide a solution to this bottleneck because of their ability to self-renew and differentiate into islet β-cells. Although progress has been […]

Generation of a functional thymus to induce immune tolerance to stem cell derivatives

Stem cell research offers the promise of replacing missing or damaged tissues in the treatment of disease. Stem-cell-derived transplants still face problems with rejection as in traditional organ transplants. Several drugs can prevent rejection but also suppress the immune system, leaving patients vulnerable to infections and cancer. To avoid rejection without using drugs requires re-educating […]