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  • About
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A CIRM Disease Team for the Treatment and Cure of Diabetes

  • Post author:
  • Post published:June 9, 2025
  • Post category:

This proposal is for the establishment of a group of faculty, staff and industrial partners to develop a proposal for a Diabetes Disease Team. Diabetes is one of the most…

Continue ReadingA CIRM Disease Team for the Treatment and Cure of Diabetes

Engineered matrices for control of lineage commitment in human pancreatic stem cells

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Patients with end-stage type 1 diabetes (T1D) can be effectively managed by allogeneic islet transplantation. However, a severe cadaveric organ shortage greatly limits use of this promising procedure. Stem cells…

Continue ReadingEngineered matrices for control of lineage commitment in human pancreatic stem cells

Generation of a functional thymus to induce immune tolerance to stem cell derivatives

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Stem cell research offers the promise of replacing missing or damaged tissues in the treatment of disease. Stem-cell-derived transplants still face problems with rejection as in traditional organ transplants. Several…

Continue ReadingGeneration of a functional thymus to induce immune tolerance to stem cell derivatives

Preclinical and clinical testing of a stem cell-based combination product for insulin-dependent diabetes

  • Post author:
  • Post published:June 9, 2025
  • Post category:

Diabetes exacts a tremendous toll on patients, their families, and society. Autoimmune Type 1 diabetes, often called juvenile-onset diabetes, is caused by a person’s own immune system mistakenly destroying their…

Continue ReadingPreclinical and clinical testing of a stem cell-based combination product for insulin-dependent diabetes

Deciphering transcriptional control of pancreatic beta-cell maturation in vitro

  • Post author:
  • Post published:June 9, 2025
  • Post category:

The loss of pancreatic beta-cells in type 1 diabetes results in absence of insulin secreted by the pancreas, and consequently elevated blood sugar which leads to various long-term complications. Diabetic…

Continue ReadingDeciphering transcriptional control of pancreatic beta-cell maturation in vitro

Biological relevance of microRNAs in hESC differentiation to endocrine pancreas

  • Post author:
  • Post published:June 9, 2025
  • Post category:

There remains an urgent and critical need for a cell-based cure of diabetes, one of the most costly diseases in California. Islet transplantation with persistent immune suppression has shown promise…

Continue ReadingBiological relevance of microRNAs in hESC differentiation to endocrine pancreas

Bone Marrow Mesenchymal Stem Cells to Heal Chronic Diabetic Wounds

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  • Post published:June 9, 2025
  • Post category:

Diabetic foot ulcers (DFU), chronic, non-healing wounds on the feet of diabetic patients, present a serious challenge to global health. These ulcers affect between 15-25% of the 18-21 million Americans…

Continue ReadingBone Marrow Mesenchymal Stem Cells to Heal Chronic Diabetic Wounds

Methods for detection and elimination of residual human embryonic stem cells in a differentiated cell product

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  • Post published:June 9, 2025
  • Post category:

Human embryonic stem cells (hESC), and other related pluripotent stem cells, have great potential as starting material for the manufacture of curative cell therapies. This is primarily for two reasons.…

Continue ReadingMethods for detection and elimination of residual human embryonic stem cells in a differentiated cell product

Developing induced pluripotent stem cells into human therapeutics and disease models

  • Post author:
  • Post published:June 9, 2025
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Human embryonic stem cells (hESCs) can undergo unlimited self-renewal and differentiate into all the cell types in the human body, and thus hold great promise for cell replacement therapy. However,…

Continue ReadingDeveloping induced pluripotent stem cells into human therapeutics and disease models

Stem cell tolerance through the use of engineered antigen-specific regulatory T cells

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  • Post published:June 9, 2025
  • Post category:

Type 1 Diabetes (T1D) occurs as a consequence of uncontrolled immune activation, culminating in the destruction of insulin-producing beta-cells. Efforts to prevent or reverse diabetes have been limited by the…

Continue ReadingStem cell tolerance through the use of engineered antigen-specific regulatory T cells
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