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Curing Hematological Diseases

  • Post author:
  • Post published:May 20, 2025
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The primary aim of this project is to develop treatments for incurable diseases of the blood and immune system. X-linked Severe Combined Immunodeficiency (X-SCID) and Fanconi anemia (FA) are two…

Continue ReadingCuring Hematological Diseases

Role of Innate Immunity in hematopoeitic stem cell-mediated allograft tolerance

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  • Post published:May 20, 2025
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The research proposed in this project has very high potential to identify new medications to boost the natural ability of stem cells to prevent rejection of transplanted organs. This is…

Continue ReadingRole of Innate Immunity in hematopoeitic stem cell-mediated allograft tolerance

Inactivating NK cell reactivity to facilitate transplantation of stem cell derived tissue

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  • Post published:May 20, 2025
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One of the great promises of stem cell research is that it will one day be possible to prepare replacement cells or organs from stem cells such as embryonic stem…

Continue ReadingInactivating NK cell reactivity to facilitate transplantation of stem cell derived tissue

Maternal and Fetal Immune Responses to In Utero Hematopoietic Stem Cell Transplantation

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  • Post published:May 20, 2025
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The immune system is the body’s defense system against disease and can recognize foreign cells. Because of this, stem cells and organs that are transplanted from one person to another…

Continue ReadingMaternal and Fetal Immune Responses to In Utero Hematopoietic Stem Cell Transplantation

Purified allogeneic hematopoietic stem cells as a platform for tolerance induction

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  • Post published:May 20, 2025
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Blood and immune cells originate and mature in the bone marrow. Bone marrow cells are mixtures of blood cells at different stages of development, and include rare populations of blood-forming…

Continue ReadingPurified allogeneic hematopoietic stem cells as a platform for tolerance induction

Development of Induced Pluripotent Stem Cells for Modeling Human Disease

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  • Post published:May 20, 2025
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Human embryonic stem cells (hESC) hold great promise in regenerative medicine and cell replacement therapies because of their unique ability to self-renew and their developmental potential to form all cell…

Continue ReadingDevelopment of Induced Pluripotent Stem Cells for Modeling Human Disease

Prospective isolation of hESC-derived hematopoietic and cardiomyocyte stem cells

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  • Post published:May 20, 2025
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The capacity of human embryonic stem cells (hESCs) to perpetuate themselves indefinitely in culture and to differentiate to all cell types of the body has lead to numerous studies that…

Continue ReadingProspective isolation of hESC-derived hematopoietic and cardiomyocyte stem cells

Improving microenvironments to promote hematopoietic stem cell development from human embryonic stem cells

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  • Post published:May 20, 2025
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Hematopoietic stem cells (HSC) have been used successfully to cure various life-threatening blood diseases. Yet, matching HSCs are not available for every patient. Human embryonic stem cells (hESC) may provide…

Continue ReadingImproving microenvironments to promote hematopoietic stem cell development from human embryonic stem cells

Generation of long-term cultures of human hematopoietic multipotent progenitors from embryonic stem cells

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  • Post published:May 20, 2025
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For many therapeutic reasons it is important to have available large numbers of blood cells. However, it is difficult to generate large numbers of specialized blood cells that have the…

Continue ReadingGeneration of long-term cultures of human hematopoietic multipotent progenitors from embryonic stem cells

Self-renewal and senescence in iPS cells derived from patients with a stem cell disease

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  • Post published:May 20, 2025
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The discovery of induced pluripotent stem (iPS) cell technology promises to revolutionize our understanding of human disease and to allow the development of new cellular therapies for regenerative medicine applications.…

Continue ReadingSelf-renewal and senescence in iPS cells derived from patients with a stem cell disease
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