Alzheimer’s Disease

Unraveling nuclear Tau functions using age-equivalent human induced neurons from healthy aging donors and tauopathy patients

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Post published:January 23, 2026
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Research Objective This project investigates how normal tau protein protects aging neurons. We'll use aging human neurons to understand how tau helps repairing DNA and why this protection fails disease.…

Drug Development of Inhibitors of Inflammation Using Human iPSC-Derived Microglia (hiMG)

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Post published:January 23, 2026
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Research Objective We will screen for modifiers of the response to misfolded αSyn and Aβ, and their cognate antibodies. Development of drugs to combat this inflammation is important in neurodegenerative…

An exosome-based translational strategy to mitigate Alzheimer’s disease neuropathology

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Post published:January 23, 2026
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Research Objective These studies will determine whether stem cell derived exosomes (nano-scale vesicles) can be used to treat the symptoms of Alzheimer’s disease (AD). Impact Our stem cell-derived exosome therapy…

Human iPSC-derived GABAergic Progenitors for Alzheimer’s Disease Treatment

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Post published:January 23, 2026
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Translational Candidate Human iPSC-derived GABAergic interneuron progenitors. Area of Impact Alzheimer's disease and related conditions. Mechanism of Action Transplantation of human iPSC-derived GABAergic progenitors, which will develop into mature GABAergic…

Human Stem-Cell Based Development of a Potent Alzheimer’s Drug Candidate

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Post published:January 23, 2026
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Over 6 million people in the US suffer from Alzheimer’s disease (AD). There are no drugs that prevent the death of nerve cells in AD, nor has any drug been…

Optimizing the differentiation and expansion of microglial progenitors from human pluripotent stem cells for the study and treatment of neurological disease.

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Post published:January 23, 2026
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Microglia are a type of immune cell within the brain that profoundly influence the development and progression of many neurological disorders. Microglia also inherently migrate toward areas of brain injury,…

Elucidating pathways from hereditary Alzheimer mutations to pathological tau phenotypes

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Post published:January 23, 2026
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We propose to elucidate pathways of genes that lead from early causes to later defects in Alzheimer’s Disease (AD), which is common, fatal, and for which no effective disease-modifying drugs…

Collection of skin biopsies to prepare fibroblasts from patients with Alzheimer’s disease and cognitively healthy elderly controls

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Post published:January 23, 2026
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Alzheimer's Disease (AD), the most common form of dementia in the elderly, affects over 5 million Americans. There are no treatments to slow progression or prevent AD. This reflects limitations…

Restoration of memory in Alzheimer’s disease: a new paradigm using neural stem cell therapy

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Post published:January 23, 2026
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Alzheimer’s disease (AD), the leading cause of dementia, results in profound loss of memory and cognitive function, and ultimately death. In the US, someone develops AD every 69 seconds and…

Stem cell based small molecule therapy for Alzheimer’s disease

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Post published:January 23, 2026
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Over 6 million people in the US suffer from AD. There are no drugs that prevent the death of nerve cells in AD, nor has any drug been identified that…

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