CIRM Funded Clinical Trials

Phase I Study of Chimeric Antigen Receptor Engineered Central Memory T cells for the Treatment of Malignant Glioma

Disease Area:
CIRM Grant:
CLIN2-10248 (Closed)
Award Value:
Trial Stage:
Phase 1
Trial Status:
Active, not recruiting
Targeted Enrollment:
82 ID:


A team at the City of Hope led by Dr. Christine Brown is pursuing a Phase 1 trial targeting an aggressive brain cancer called malignant glioma. City of Hope will re-engineer a patient’s immune system central memory T cells (TCM cells) to express chimeric antigen receptors (CAR). These CAR-T cells will recognize a molecular marker on the surface of glioma cancer stem cells and kill the tumors. Dr. Brown’s award to pursue CAR-T therapy for solid cancers comes at an exciting and opportune time with the recent U.S. Food and Drug Administration (FDA) approval of the first CAR-T therapy, called Kymriah, for patients with acute lymphoblastic leukemia, a deadly form of blood cancer.


Non-randomized, open-label treatment.


Determine safety, feasibility, and efficacy.

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