CIRM Funded Clinical Trials

A Phase 1b/2a Study of the ROR1-Targeting Monoclonal Antibody, Cirmtuzumab, and the Bruton Tyrosine Kinase Inhibitor, Ibrutinib, in B-Cell Cancers

Disease Area:
B cell cancers, Leukemia
CIRM Grant:
CLIN2-10192 (Closed)
Award Value:
Trial Stage:
Phase 1/2
Trial Status:
Active, not recruiting
Targeted Enrollment:
102 ID:


Cancer is a leading cause of death in California. Many cancers resist current therapies due to therapy-resistant cancer stem cells (CSCs). A team at UCSD is testing an antibody therapy called cirmtuzumab in a clinical trial study to treat a blood cancer, Chronic Lymphocytic Leukemia (CLL). The antibody recognizes and attaches to a protein on the surface of cancer stem cells. This attachment disables the protein which slows the growth of the leukemia and makes it more vulnerable to anti-cancer drugs. The team is also testing cirmtuzumab in combination with an approved cancer fighting drug called ibrutinib, to target can- cer stem cells in a separate clinical trial. The aim is that combining cirmtuzumab with ibrutinib will improve cancer remission and long-term cancer control in patients. 


Open label. Phase 1b dose finding, followed by Phase 2a.


Evaluate dosing and complete response rate.

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