Statement of Benefit to California:
Year 1The Developmental Biology and Regenerative Medicine Research Program of The Saban Research Institute seeks to discover the basic mechanisms of stem and progenitor cell function in human organ development, and apply them to tissue repair and regeneration. Recent advances in developmental biology hold great promise in many areas of human adult as well as child health, where organ regeneration, stem cell based therapy or tissue engineering could be life saving. Under this CIRM training grant, Fellows are devising therapeutic targets for eventual translation to the bedside including lung hypoplasia or injury caused by prematurity or aging, short gut, kidney diseases, heart regeneration and diabetes. The training environment in this CIRM program brings clinical surgery and pediatric medicine together with basic research and is organized into organ-based sections that train Fellows to carry out scientific inquiries within the overall program focus of organogenesis, injury repair, tissue regeneration and engineering.
Year 2To date this CIRM Training grant has trained 19 PhD qualified and 10 MD qualified scientists in stem cell related topics, ranging from the basic biology of stem cells to translational applications of stem cell therapies across the spectrum of organ malformations and diseases in children as well as in adult health.
Highlights of our success include tissue engineering the intestine, cell based therapies for kidney diseases and lung fibrosis to name but a few. Graduates of this CIRM training program are continuing to work in California (as researchers at CHLA, faculty at USC,and positions held at Harbor UCLA, Leica, Cedars Sinai Medical Center, etc.), out-of-state as clinician doctors at New York City & Maryland, and around the world (EMBL Australia and University of Cologne) to discover the properties of stem cells and apply them to new translational treatments for a wide range of organ based regenerative solutions.