Basic Biology III

RFA 10-04: CIRM Basic Biology Awards III

The CIRM Basic Biology Awards III will fund research grants to investigate basic mechanisms underlying stem cell biology, cellular plasticity, and cellular differentiation. Studies supported by these awards will form the foundation for future translational and clinical advances, enabling the realization of the full potential of human stem cells and reprogrammed cells for therapies and as tools for biomedical innovation.

For this RFA, the Japanese Science and Technology Agency (JST) and the Federal Ministry For Education and Research, Germany (BMBF) will participate as Collaborative Funding Partners. Appendices A and B describe additional requirements and procedures for applicants whose proposals include a Japanese or German collaborator to be funded by the JST or BMBF, respectively.

Please see the RFA for full details.

RFA 10-04: CIRM Basic Biology III Awards [pdf] (amended 9.16.10 to update online submission instructions)

Appendix A (JST) [pdf]
Appendix B (BMBF) [pdf]

Application Process

Submission of an application for the CIRM Basic Biology Awards III RFA involves a two-step process. An eligible PI may submit one Preliminary Application (PreApp). PreApps will be evaluated by scientific specialists from outside California who are experts in specific areas of research described in the PreApp and by CIRM scientific staff, based on the scientific review criteria described in section VII of this RFA. Applicants whose projects are judged as most promising, competitive, and responsive to the RFA will be invited to submit a full Application. All other applicants will be deferred, with the opportunity to apply in response to a future RFA.

Preliminary Application Instructions

Preliminary Applications must be submitted online using the CIRM Grants Management Portal at http://grants.cirm.ca.gov.

Each PI may submit only a single PreApp for this RFA.

The deadline for submission is 5:00 pm (PDT) on October 7, 2010. No exceptions to this deadline will be made.

To submit a Preliminary Application:

1. Go to the Grants Management Portal (https://grants.cirm.ca.gov/login/upgrade_browser) and log in with your existing CIRM Username and Password. If you do not have a Username, Click on the “New User” link and follow the instructions to create a CIRM Username and password.

2. After logging in, your home page will display a list of open RFAs. Click on the “Apply for this grant” link corresponding to the Basic Biology Award III.

3. Complete each section by clicking on the appropriate link and following the posted instructions. RBE (if applicable) and signature page templates can be found in the “Upload Required Documents” section.

4. The “Done with Preliminary Application” button becomes enabled when all sections are complete and all required documents have been uploaded. Once “Done with Preliminary Application” has been selected, you will no longer be able to make changes to your Preliminary Application.

5. To ensure the process is complete, go back to your home page and check the list under “Your Preliminary Applications“. The status for Basic Biology Award III should be “submitted“.

The Preliminary Application must be received by CIRM no later than 5:00 pm (PDT) on October 7, 2010 via the online submission process. No exceptions to this deadline will be made.

Full Application Process

Full Applications will only be accepted from applicants who 1) submitted a PreApp and 2) are invited by CIRM to submit a full Application.

The full Application consists of four parts: Part A: Application Information Form, Part B: Basic Biology Award Research Proposal, Part C: Biographical Sketches for Key Personnel, and Part D: Related Business Entities Disclosure Form. All four parts of the full Application for CIRM Basic Biology Awards III must be submitted together and received by CIRM no later than 5:00 pm (PST) on January 19, 2011, in both electronic form and in hard copy (a signed original and five copies). It is the applicant’s responsibility to meet this deadline; no exceptions will be made.

Submit electronic copies of all 4 parts of the application online using the CIRM Grants Management Portal at https://grants.cirm.ca.gov/login/upgrade_browser. In addition to the electronic submittal, send an original copy of the application signed by both the PI and the institution’s Authorized Organizational Official (AOO), plus 5 copies of the full Application (preferably double-sided) to:

Basic Biology Awards III Application
California Institute for Regenerative Medicine
210 King Street
San Francisco, CA 94107

You will need a fully functional copy of Adobe Acrobat version 8 or 9 (Standard or Professional) to complete, print, and save Parts A and D of the full Application. We recommend using Adobe Acrobat version 8.1 (or the latest version). Using Adobe Acrobat Reader will not permit you to save information that is entered in the form.

View complete application instructions and forms.

Schedule of CIRM deadlines and reviews	Date
Pre-Applications due	5:00 pm (PDT), October 7, 2010
Invitations for full Applications sent out by CIRM	December 17, 2010
Full Applications due	5:00 pm (PST), January 19, 2011
Review of full Applications by Grants Working Group (GWG)	March, 2011
Review and Approval by ICOC	May, 2011
Earliest Funding of Awards	Summer, 2011

No exceptions will be made to the indicated deadlines.

ICOC Approval:

May 4, 2011

Total Awards:

Award Value:

$35,179,295

Awards

Institution	Investigator	Grant Title	Award Value
City of Hope, Beckman Research Institute	Dr. Jiing-Kuan Yee Ph.D.	Use of human iPS cells to study spinal muscular atrophy	$1,268,868
University of California, Los Angeles	Dr. Yi Eve Sun	Studying neurotransmission of normal and diseased human ES cell-derived neurons in vivo	$1,382,400
University of California, San Diego	Dr. Deborah H Spector Dr.	Viral-host interactions affecting neural differentiation of human progenitors	$1,372,660
Stanford University	Dr. Aaron J Hsueh	Correlated time-lapse imaging and single cell molecular analysis of human embryo development	$1,259,733
University of California, Los Angeles	Dr. Kathrin Plath Dr.	Discovery of mechanisms that control epigenetic states in human reprogramming and pluripotent cells	$1,364,598
University of California, San Diego	Dr. David A. Cheresh	Molecular basis of human ES cell neurovascular differentiation and co-patterning	$1,359,996
University of California, San Diego	Dr. Anirvan Ghosh Dr.	Investigation of synaptic defects in autism using patient-derived induced pluripotent stem cells	$843,597
University of California, San Diego	Dr. Kun Zhang	Functional characterization of mutational load in nuclear reprogramming and differentiation	$1,295,318
University of California, San Francisco	Jason Harris Pomerantz	Phenotypic Analysis of Human ES Cell-Derived Muscle Stem Cells	$1,381,296
Scripps Research Institute	Dr. Joel M Gottesfeld	Triplet Repeat Instability in Human iPSCs	$1,705,494
University of California, San Diego	Gene Wei-Ming Yeo	Neural and general splicing factors control self-renewal, neural survival and differentiation	$1,287,619
Gladstone Institutes, J. David	Dr. Deepak Srivastava	Mechanisms of Direct Cardiac Reprogramming	$1,572,380
Stanford University	Sean M. Wu	Elucidating Molecular Basis of Hypertrophic Cardiomyopathy with Human Induced Pluripotent Stem Cells	$1,260,537
University of California, Los Angeles	Dr. Ali Nsair MD	Characterization and Engineering of the Cardiac Stem Cell Niche	$1,127,741
Stanford University	Dr. Michael F Clarke	USP16 controls stem cell number: implications for Down Syndrome	$1,263,826
University of California, San Francisco	Dr. John P Murnane Dr.	Genomic instability during culturing of human embryonic stem cells	$1,070,919
University of California, San Diego	Dr. Benhai Zheng Dr.	Generation and characterization of corticospinal neurons from human embryonic stem cells	$1,355,063
Stanford University	Dr. Joanna Wysocka PhD	Enhancer-mediated gene regulation during early human embryonic development	$1,420,618
University of California, San Diego	Dr. Farah Sheikh Dr.	Molecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC	$1,341,955
University of California, Los Angeles	Dr. William Lowry Dr.	Molecular determinants of accurate differentiation from human pluripotent stem cells	$677,115
University of California, Los Angeles	Dr. Shuo Lin Dr.	Etsrp/ER71 mediated stem cell differentiation into vascular lineage	$1,378,781
Parkinson’s Institute	R. Jeremy Nichols	Understanding the role of LRRK2 in iPSC cell models of Parkinson’s Disease	$1,482,822
Scripps Research Institute	Dr. Kristin K Baldwin Dr.	Identifying sources of mutation in human induced pluripotent stem cells by whole genome sequencing	$1,705,500
University of California, Berkeley	Dr. Michael P. Rapé Dr.	Ubiquitin-dependent control of hESC self-renewal and expansion	$1,224,805
University of California, Los Angeles	Dr. Gay Miriam Crooks	Forming the Hematopoietic Niche from Human Pluripotent Stem Cells	$1,252,857
University of California, San Diego	Dr. Charles C. King Dr.	Biological relevance of microRNAs in hESC differentiation to endocrine pancreas	$1,313,649
University of California, Berkeley	Dr. Song Li	Induced Pluripotent Stem Cells for Tissue Regeneration	$1,209,148
			Total: $35,179,294.96