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Programming Human ESC-derived Neural Stem Cells with MEF2C for Transplantation in Stroke

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  • Post published:December 9, 2025
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The goal of this project is to produce a stem cell-based therapy for stroke (also known as an ischemic cerebral infarct). Stroke is the third leading cause of death in…

Continue ReadingProgramming Human ESC-derived Neural Stem Cells with MEF2C for Transplantation in Stroke

Programming Human ESC-derived Neural Stem Cells with MEF2C for Transplantation in Stroke

  • Post author:
  • Post published:December 9, 2025
  • Post category:

The goal of this project is to produce a stem cell-based therapy for stroke (also known as an ischemic cerebral infarct). Stroke is the third leading cause of death in…

Continue ReadingProgramming Human ESC-derived Neural Stem Cells with MEF2C for Transplantation in Stroke

Progenitor Cells Secreting GDNF for the Treatment of ALS

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  • Post published:December 9, 2025
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This project aims to use a powerful combined neural progenitor cell and growth factor approach to treat patients with amyotrophic lateral sclerosis (ALS or Lou Gehrig’s Disease). ALS is a…

Continue ReadingProgenitor Cells Secreting GDNF for the Treatment of ALS

Phase I study of IM Injection of VEGF-Producing MSC for the Treatment of Critical Limb Ischemia

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  • Post published:December 9, 2025
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Critical limb ischemia (CLI) represents a significant unmet medical need without any approved medical therapies for patients who fail surgical or angioplasty procedures to restore blood flow to the lower…

Continue ReadingPhase I study of IM Injection of VEGF-Producing MSC for the Treatment of Critical Limb Ischemia

MSC engineered to produce BDNF for the treatment of Huntington’s disease

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  • Post published:December 9, 2025
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One in every ten thousand people in the USA has Huntington's disease, and it impacts many more. Multiple generations within a family can inherit the disease, resulting in escalating health…

Continue ReadingMSC engineered to produce BDNF for the treatment of Huntington’s disease

Human ES cell based therapy of heart failure without allogenic immune rejection

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  • Post published:December 9, 2025
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Heart failure is a major and ever-growing health problem affecting an estimated 5.8 million Americans with about half a million new cases every year. There are limited therapeutic options for…

Continue ReadingHuman ES cell based therapy of heart failure without allogenic immune rejection

Neural Stem Cells as a Developmental Candidate to Treat Alzheimer Disease

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  • Post published:December 9, 2025
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Alzheimer disease (AD), the most common cause of dementia among the elderly and the third leading cause of death, presently afflicts over 5 million people in the USA, including over…

Continue ReadingNeural Stem Cells as a Developmental Candidate to Treat Alzheimer Disease

Sustained siRNA production from human MSC to treat Huntingtons Disease and other neurodegenerative disorders

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  • Post published:December 9, 2025
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One in every ten thousand people in the USA have Huntington's Disease, and it impacts many more. Multiple generations within a family can inherit the disease, resulting in escalating health…

Continue ReadingSustained siRNA production from human MSC to treat Huntingtons Disease and other neurodegenerative disorders

Stem Cell-Mediated Oncocidal Gene Therapy of Glioblastoma (GBM)

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  • Post published:December 9, 2025
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Brain tumors (BTs) are incurable, whether they start in the brain or spread there from other sites. Despite advances in surgical, radiation, pharmacologic, and gene therapies, survival with a BT…

Continue ReadingStem Cell-Mediated Oncocidal Gene Therapy of Glioblastoma (GBM)

Stem Cell-mediated Therapy for High-grade Glioma: Toward Phase I-II Clinical Trials

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  • Post published:December 9, 2025
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Despite aggressive multimodal therapy and advances in imaging, surgical and radiation techniques, malignant brain tumors (high-grade gliomas) remain incurable, with survival often measured in months. Treatment failure is largely attributable…

Continue ReadingStem Cell-mediated Therapy for High-grade Glioma: Toward Phase I-II Clinical Trials
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