Determining how age-specific heterogeneity of human hematopoietic stem cells and megakaryocyte progenitors contribute to thrombotic disease upon aging

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Research Objective Our research will determine how aging of human blood stem cells leads to dramatic increases in disorders of platelets, cells that normally prevent bleeding but form harmful clots…

Continue ReadingDetermining how age-specific heterogeneity of human hematopoietic stem cells and megakaryocyte progenitors contribute to thrombotic disease upon aging

Identification of antigenic neo-epitopes from in vitro reprogrammed human tissue precursors for regenerative therapy

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Research Objective This study examine potential immunologic changes caused by cellular reprogramming that could present a barrier to clinical application of regenerative therapies. Impact Identification and evaluation of immunologic changes…

Continue ReadingIdentification of antigenic neo-epitopes from in vitro reprogrammed human tissue precursors for regenerative therapy