Molecular Characterization of hESC and hIPSC-Derived Spinal Motor Neurons
One of the main objectives of stem cell biology is to create physiologically relevant cell types that can be used to either facilitate the study of or directly treat human…
Human Cardiovascular Progenitors, their Niches and Control of Self-renewal and Cell Fate
For the millions of Americans who are born with or develop heart disease, stem cell research offers the first hope of reversing or repairing heart muscle damage. Thus, early reports…
Defining the molecular mechanisms of somatic cell reprogramming
The development of methods to “reprogram” adult cells such as skin cells by simultaneously expressing four specific factors — Oct3/4, Sox2, c-Myc and Klf4 — in order to create cells…
Molecular Mechanisms of Reprogramming towards Pluripotency
Stem cell biology and its applications to cell-based therapies, since its inception 30 years ago, has been hindered by the immunological considerations of rejection of non-autologous cells in patients, as…
Molecular Characterization and Functional Exploration of Hemogenic Endothelium
Hematopoietic cells are responsible for generating all cell types present in the blood and therefore critical for the provision of oxygen and nutrients to all the tissues in the body.…
Multi-gene modulation to rescue CNS-associated microdeletion syndromes
Research Objective Chromosomal microdeletion syndromes result in severe neuropsychiatric syndromes and lack therapy. This proposal will define critical genomic regions needed to generate new tools for functional rescue. Impact This…
Global profiling of miRNA-based gene activation to enable a new category of genetic medicine
Research Objective The proposed research will address key knowledge gaps in small activating RNAs (saRNAs) and could overcome bottlenecks limiting the broader adoption of this technology for regenerative medicine Impact…
Dissecting the cellular and molecular interactions between embryo and endometrium during human implantation.
Research Objective This research will define the dynamic mechanisms of human embryo implantation by integrating live imaging, spatial multi-omics, and gene editing in physiologically relevant stem cell-based models. Impact This…
Identifying and Overcoming Roadblocks to Hearing Restoration Using Human Induced Pluripotent Stem Cells
Research Objective To utilize human iPSCs as an in vitro model of hearing loss and overcome obstacles to hair cell regeneration by prompting post-mitotic supporting cells to re-enter the cell…
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