Improved hES Cell Growth and Differentiation
Human embryonic stem (hES) cells are pluripotent stem cells that can theoretically give rise to every cell type in the human body. Consequently, hES cells have enormous promise for the…
Regulated Expansion of Lympho-hematopoietic Stem and Progenitor Cells from Human Embryonic Stem Cells (hESC)
The clinical potential of human embryonic stem cells (hESC) for transplantation will be realized only when we can develop methods to control the process of tissue differentiation far more efficiently…
Regulated Expansion of Lympho-hematopoietic Stem and Progenitor Cells from Human Embryonic Stem Cells (hESC)
The clinical potential of human embryonic stem cells (hESC) for transplantation will be realized only when we can develop methods to control the process of tissue differentiation far more efficiently…
Human stem cell derived oligodendrocytes for treatment of stroke and MS
Strokes that affect the nerves cells, i.e., “gray matter”, consistently receive the most attention. However, the kind of strokes that affecting the “wiring” of the brain, i.e., “white matter”, cause…
Modeling Myocardial Therapy with Human Embryonic Stem Cells
Five million people in the U.S. suffer with heart failure, at a cost of $30 billion/year. Heart failure occurs when the heart is damaged and becomes unable to meet the…
Guiding the developmental program of human embryonic stem cells by isolated Wnt factors
Just like cells in a human embryo, embryonic stem cells have the potential to give rise to all cell types and tissues in a human body. That is why it…
Epigenetic gene regulation during the differentiation of human embryonic stem cells: Impact on neural repair
Human embryonic stem cells (hESCs) have the potential to become all sorts of cells in human body including nerve cells. Moreover, hESCs can be expanded in culture plates into a…
Spinal ischemic paraplegia: modulation by human embryonic stem cell implant.
schemia-induced paraplegia often combined with a qualitatively defined increase in muscle tone (i.e. spasticity and rigidity) is a serious complication associated with a temporary aortic cross-clamping ( a surgical procedure…
microRNA Regulation of Cardiomyocyte Differentiation from Human Embryonic Stem Cells
Regenerative therapies could be particularly beneficial for heart disease, which is the leading killer of adults in the U.S, and is responsible for the 5 million Americans with insufficient cardiac…
Molecular and Cellular Transitions from ES Cells to Mature Functioning Human Neurons
Human embryonic stem cells (hESCs) are pluripotent entities, capable of generating a whole-body spectrum of distinct cell types. We have developmental procedures for inducing hESCs to develop into pure populations…
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